Zirconia toughened alumina (ZTA) powders: ultrastructural and histological analysis

Maria Silvia Spinelli, Giulio Maccauro, C. Graci, Calogero Graci, A. Cittadini, Achille Renato Maria Cittadini, G. Magnani, S. Sangiorgi, V. Del Bravo, Valentina Del Bravo, Paolo Francesco Manicone, Luca Raffaelli, F. Muratori, Francesco Muratori, Alessandro Sgambato

Risultato della ricerca: Contributo in rivistaArticolo in rivista

4 Citazioni (Scopus)


Ceramic materials, as Alumina and Zirconia, has made an improvement in the choice of new biomaterials for the load bearing application in dental and orthopaedic implants. These materials has shown mechanical resistance to high stress related to weight bearing and low debris in time. For this reason they are indicated on young patients implant, with high demanding activities and long life expectance. In literature however the risk of chronic inflammation due to chronic wear debris release and the possibility of carcinogenesis, is still to be definitively investigated. Another point to investigate is the acute reaction of the tissue in case of acute release of powders of these materials. The aim of this study was to investigate the possible local and systemic acute effects of ceramic precursors in form of powders of different size when released into articular joint. Powders of ZTA were implanted in the knee joint of twenty-four New Zealand white adult rabbits, that were sacrificed at 1,3,6, and 12 months. Radiographic, histological and immunoistochemestry analysis were conducted on periprosthetic tissue and peripheral organs, to verifying local host response and systemic toxic effects.
Lingua originaleEnglish
pagine (da-a)153-156
Numero di pagine4
RivistaInternational Journal of Immunopathology and Pharmacology
Stato di pubblicazionePubblicato - 2011


  • Aluminum Oxide
  • Ceramics
  • Powders
  • Zirconium


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