TY - JOUR
T1 - Zika virus infection induces MiR34c expression in glioblastoma stem cells: new perspectives for brain tumor treatments
AU - Iannolo, Gioacchin
AU - Sciuto, Maria Rita
AU - Cuscino, Nicola
AU - Pallini, Roberto
AU - Douradinha, Bruno
AU - Ricci Vitiani, Lucia
AU - De Maria Marchiano, Ruggero
AU - Conaldi, Pier Giulio
PY - 2019
Y1 - 2019
N2 - Zika virus (ZIKV) is a flavivirus with a marked effect on fetal nervous system development. ZIKV treatment has recently been found to also have a benefit against glioblastoma, a highly aggressive brain tumor with a poor prognosis. The reported data do not completely explain the mechanism beyond this effect. Nevertheless, in the majority of the cases no adverse effect has been found in healthy adult humans. In this study, we characterized the ZIKV infection mechanism on glioblastoma stem cells, which are considered responsible for the tumor progression and resistance to conventional therapies. Moreover, we explain why the action of this virus is directed to the stem cells in the nervous system counterpart. Our results confirm the effectiveness of ZIKV treatment against glioblastoma, indicating novel molecular targets that can be introduced for more powerful therapies.
AB - Zika virus (ZIKV) is a flavivirus with a marked effect on fetal nervous system development. ZIKV treatment has recently been found to also have a benefit against glioblastoma, a highly aggressive brain tumor with a poor prognosis. The reported data do not completely explain the mechanism beyond this effect. Nevertheless, in the majority of the cases no adverse effect has been found in healthy adult humans. In this study, we characterized the ZIKV infection mechanism on glioblastoma stem cells, which are considered responsible for the tumor progression and resistance to conventional therapies. Moreover, we explain why the action of this virus is directed to the stem cells in the nervous system counterpart. Our results confirm the effectiveness of ZIKV treatment against glioblastoma, indicating novel molecular targets that can be introduced for more powerful therapies.
KW - zika
KW - zika
UR - http://hdl.handle.net/10807/167055
U2 - 10.1038/s41419-019-1499-z
DO - 10.1038/s41419-019-1499-z
M3 - Article
SN - 2041-4889
VL - 10
SP - N/A-N/A
JO - CELL DEATH & DISEASE
JF - CELL DEATH & DISEASE
ER -
