Zika virus infection induces MiR34c expression in glioblastoma stem cells: new perspectives for brain tumor treatments

Roberto Pallini, Ruggero De Maria Marchiano, Gioacchin Iannolo, Maria Rita Sciuto, Nicola Cuscino, Bruno Douradinha, Lucia Ricci Vitiani, Pier Giulio Conaldi

Risultato della ricerca: Contributo in rivistaArticolo in rivista

7 Citazioni (Scopus)

Abstract

Zika virus (ZIKV) is a flavivirus with a marked effect on fetal nervous system development. ZIKV treatment has recently been found to also have a benefit against glioblastoma, a highly aggressive brain tumor with a poor prognosis. The reported data do not completely explain the mechanism beyond this effect. Nevertheless, in the majority of the cases no adverse effect has been found in healthy adult humans. In this study, we characterized the ZIKV infection mechanism on glioblastoma stem cells, which are considered responsible for the tumor progression and resistance to conventional therapies. Moreover, we explain why the action of this virus is directed to the stem cells in the nervous system counterpart. Our results confirm the effectiveness of ZIKV treatment against glioblastoma, indicating novel molecular targets that can be introduced for more powerful therapies.
Lingua originaleEnglish
pagine (da-a)N/A-N/A
RivistaCELL DEATH & DISEASE
Volume10
DOI
Stato di pubblicazionePubblicato - 2019

Keywords

  • zika

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