Y-chromosome STR loci in Sardinia and continental Italy reveal islander-specific haplotypes

A Caglià, A Novelletto, Marina Dobosz, P. Malaspina, B. M Ciminelli, Vincenzo Lorenzo Pascali

Risultato della ricerca: Contributo in rivistaArticolo in rivista

34 Citazioni (Scopus)


Six Y-linked tetranucleotide microsatellites were typed in a sample of continental Italians and Sardinians. Significant differences in allele distributions were found between peninsular Italy and the island. Patterns of distinct allelic associations were evident in Sardinia and in the mainland. STR haplotypes in a subset of Sardinian chromosomes were monophyletically related and indicated that additions/deletions of a single tetranucleotide unit had to sequentially occur within a historical time-scale (about 9,000 years). Assumptions on both the time elapsed since the peopling of the island and the number of mutational events led us to estimate (by three different methods) a rate of 2.7-11 x 10(-4) mutations per generation per locus--at the upper end of the range of values reported in the literature.
Lingua originaleEnglish
pagine (da-a)288-292
Numero di pagine5
RivistaEuropean Journal of Human Genetics
Stato di pubblicazionePubblicato - 1997


  • Gene Frequency
  • Genetic Variation/genetics
  • Haplotypes
  • Microsatellite Repeats/genetics
  • Phylogeny
  • Y Chromosome/genetics


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