Xanthan gum-based materials for omega-3 PUFA delivery: Preparation, characterization and antineoplastic activity evaluation.

Simona Serini, Gabriella Calviello, Sonia Trombino, Roberta Cassano

Risultato della ricerca: Contributo in rivistaArticolo in rivistapeer review

11 Citazioni (Scopus)

Abstract

Xanthan gum-based microspheres and hydrogels, useful for targeted colorectal release of omega-3 polyunsaturated fatty acids (PUFAs), were successfully prepared and characterized. In particular, the microsphere size,as well as the hidrogel swelling degree at pH7.4, and the omega-3 PUFA loading efficiency of both the materials suggested their suitability for colorectal delivery. Moreover, the antioxidant efficiency of the xanthan gum based materials suggests their ability to protect the omega-PUFA cargo. We demonstrated that α-linolenic acid (ALA 18:3ω-3) carried by the materials increased significantly its ability to reduce colorectal cancer cell growth in vitro.On the contrary, docosahexaenoic acid (DHA, 22:6ω-3) enclosed in the hydrogel formulation did not enhance its already high anti-neoplastic potential. The improved anti-neoplastic efficacy of ALA enclosed in both the xanthan gum-based formulations further supports the hypothesis of a potential use of this omega-3 PUFA as a suitable and more sustainable alternative to thefish-derived DHA.
Lingua originaleEnglish
pagine (da-a)431-440
Numero di pagine10
RivistaCarbohydrate Polymers
DOI
Stato di pubblicazionePubblicato - 2019

Keywords

  • Carrier delivery
  • Colon cancer cells
  • Hydrogels
  • Omega-3
  • Targeted treatment
  • Xanthan gum

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