X-Ray-Induced Lysis of the Fe-CO Bond in Carbonmonoxy-Myoglobin

Alessandro Arcovito, Stefano Della Longa

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8 Citazioni (Scopus)


By using X-ray absorption near edge structure (XANES) spectroscopy, we show that under prolonged exposure to Synchrotron X-rays, at T < 10 K, the Fe-heme in carbonmonoxy-myoglobin (MbCO) undergoes a slow two-state transition process. The final spectrum is nearly identical to that of the classical photoproduct (Mb*CO) obtained by UV−visible light illumination at 15 K. By increasing the temperature, the starting spectrum of MbCO is recovered at T > 100 K, demonstrating that the process is reversible and no damage occurred at the heme site in the time course of the experiment. Thus, the overall X-ray-induced process at low temperature is identical to the well-known (light-induced) photolysis of CO-hemeproteins.
Lingua originaleEnglish
pagine (da-a)9958-9961
Numero di pagine4
RivistaInorganic Chemistry
Stato di pubblicazionePubblicato - 2010


  • low temperature
  • myoglobin
  • photolysis


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