Working the endless puzzle of hereditary autoinflammatory disorders

Donato Rigante, F Caso, L Cantarini, Om Lucherini, P Sfriso, M Fioretti, L Costa, A Vitale, M Atteno, M Galeazzi, I Muscari, F Magnotti, B Frediani, L Punzi

Risultato della ricerca: Contributo in rivistaArticolo in rivista

Abstract

Hereditary autoinflammatory disorders encompass manifold dysfunctions of innate immunity caused by mutations in genes coding for the main characters of the inflammatory scene: most of these conditions have an early onset, ranging from the first days of life to the first decades, and include hereditary periodic fevers, NLRP-related diseases, granulomatous and pyogenic syndromes, which are basically characterized by upturned inflammasome activity and overproduction of bioactive interleukin (IL)-1β and other proinflammatory cytokines. The discovery of a causative link between autoinflammation and IL-1β release has improved our understanding of the intimate mechanisms of innate immunity, and has likewise led to the identification of extraordinary treatments for many of these disorders.
Lingua originaleEnglish
pagine (da-a)N/A-N/A
RivistaModern Rheumatology
Volume2013
Stato di pubblicazionePubblicato - 2013

Keywords

  • Autoinflammation

Fingerprint Entra nei temi di ricerca di 'Working the endless puzzle of hereditary autoinflammatory disorders'. Insieme formano una fingerprint unica.

Cita questo