TY - JOUR
T1 - Within-day and between-day repeatability of measurements with an electronic nose in patients with COPD
AU - Bofan, Maria
AU - Mores, Nadia
AU - Baron, Marco
AU - Dabrowska, Malgorzata
AU - Valente, Salvatore
AU - Schmid, Maurizio
AU - Trové, Andrea
AU - Trove', Andrea
AU - Conforto, Silvia
AU - Zini Tanzi, Gina
AU - Cattani Franchi, Paola
AU - Fuso, Leonello
AU - Mautone, Antonella
AU - Mondino, Chiara
AU - Pagliari, Gabriella
AU - D'Alessio, Tommaso
AU - Montuschi, Paolo
PY - 2013
Y1 - 2013
N2 - Electronic noses (e-noses), artificial sensor systems generally consisting of chemical sensor arrays for the detection of volatile compound profiles, have potential applications in respiratory medicine. We assessed within-day and between-day repeatability of an e-nose made from 32 sensors in patients with stable chronic obstructive pulmonary disease (COPD). We also compared between-day repeatability of an e-nose, fraction of exhaled nitric oxide (FENO) and pulmonary function testing. Within-day and between-day repeatability for the e-nose was assessed in two breath samples collected 30 min and seven days apart, respectively. Repeatability was expressed as an intraclass correlation coefficient (ICC). All sensors had ICC above 0.5, a value that is considered acceptable for repeatability. Regarding within-day repeatability, ICC ranged from 0.75 to 0.84 (mean = 0.80 ± 0.004). Sensors 6 and 19 were the most reproducible sensors (both, ICC = 0.84). Regarding between-day repeatability, ICC ranged from 0.57 to 0.76 (mean = 0.68 ± 0.01). Sensor 19 was the most reproducible sensor (ICC = 0.76). Within-day e-nose repeatability was greater than between-day repeatability (P < 0.0001). Between-day repeatability of FENO (ICC = 0.91) and spirometry (ICC range = 0.94-0.98) was greater than that of e-nose (mean ICC = 0.68). In patients with stable COPD, the e-nose used in this study has acceptable within-day and between-day repeatability which varies between different sensors
AB - Electronic noses (e-noses), artificial sensor systems generally consisting of chemical sensor arrays for the detection of volatile compound profiles, have potential applications in respiratory medicine. We assessed within-day and between-day repeatability of an e-nose made from 32 sensors in patients with stable chronic obstructive pulmonary disease (COPD). We also compared between-day repeatability of an e-nose, fraction of exhaled nitric oxide (FENO) and pulmonary function testing. Within-day and between-day repeatability for the e-nose was assessed in two breath samples collected 30 min and seven days apart, respectively. Repeatability was expressed as an intraclass correlation coefficient (ICC). All sensors had ICC above 0.5, a value that is considered acceptable for repeatability. Regarding within-day repeatability, ICC ranged from 0.75 to 0.84 (mean = 0.80 ± 0.004). Sensors 6 and 19 were the most reproducible sensors (both, ICC = 0.84). Regarding between-day repeatability, ICC ranged from 0.57 to 0.76 (mean = 0.68 ± 0.01). Sensor 19 was the most reproducible sensor (ICC = 0.76). Within-day e-nose repeatability was greater than between-day repeatability (P < 0.0001). Between-day repeatability of FENO (ICC = 0.91) and spirometry (ICC range = 0.94-0.98) was greater than that of e-nose (mean ICC = 0.68). In patients with stable COPD, the e-nose used in this study has acceptable within-day and between-day repeatability which varies between different sensors
KW - chronic obstructive pulmonary disease (COPD)
KW - electronic nose
KW - repeatability of measurements
KW - chronic obstructive pulmonary disease (COPD)
KW - electronic nose
KW - repeatability of measurements
UR - http://hdl.handle.net/10807/118558
U2 - 10.1088/1752-7155/7/1/017103
DO - 10.1088/1752-7155/7/1/017103
M3 - Article
SN - 1752-7155
VL - 7
SP - N/A-N/A
JO - Journal of Breath Research
JF - Journal of Breath Research
ER -