Why docosahexaenoic acid and aspirin supplementation could be useful in women as a primary prevention therapy against Alzheimer's disease?

Giovanni Gambassi, Carlo Masullo, Massimo Pomponi, Massimiliano Pomponi, Annamaria Di Gioia

Risultato della ricerca: Contributo in rivistaArticolo in rivista

14 Citazioni (Scopus)

Abstract

The assumption that disease specific risk factors are similar or the same in men and women may lead to incorrect primary prevention strategies. This study focused on the evaluation of gender-specific Alzheimer's disease (AD) risk factors. In AD, female gender appears to be an important risk factor associated with the aberrant production of beta amyloid (βA) peptides. Although decreased levels in plasma DHA concentration are associated with cognitive decline in healthy elderly and Alzheimer's patients, pre-treatment with DHA significantly reduced the survival of cortical neurons incubated with beta amyloid (βA). Hence, in the presence of an increasing amount of βA, paradoxically women - who have higher plasma levels of DHA - are more likely to develop AD. Aspirin (ASA) converts cyclooxygenase (COX)-2 into a form that generates new neuroprotective docosanoids from DHA; therefore, ASA might positively resolve the paradoxical effect of the concomitant presence of DHA and βA.
Lingua originaleEnglish
pagine (da-a)124-131
Numero di pagine8
RivistaAgeing Research Reviews
Volume10
DOI
Stato di pubblicazionePubblicato - 2011

Keywords

  • Aged
  • Alzheimer Disease
  • Amyloid beta-Peptides
  • Anti-Inflammatory Agents, Non-Steroidal
  • Apolipoproteins E
  • Aspirin
  • Brain-Derived Neurotrophic Factor
  • Docosahexaenoic Acids
  • Female
  • Hippocampus
  • Humans
  • Neocortex
  • Neural Pathways
  • Peroxisome Proliferator-Activated Receptors
  • Risk Factors
  • Women

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