TY - JOUR
T1 - Whole blood EBV-DNA predicts outcome in diffuse large B-cell lymphoma
AU - Tisi, Maria Chiara
AU - Cupelli, Elisa
AU - Santangelo, Rosaria
AU - Maiolo, Elena
AU - Alma, Eleonora
AU - Giachelia, Manuela
AU - Martini, Maurizio
AU - Bellesi, Silvia
AU - D'Alo', Francesco
AU - Voso, Maria Teresa
AU - Pompili, Maurizio
AU - Leone, Giuseppe
AU - Larocca, Luigi Maria
AU - Hohaus, Stefan
PY - 2016
Y1 - 2016
N2 - An association between Epstein-Barr Virus (EBV) infection and lymphoproliferative diseases has been reported with EBV + diffuse large B cell-lymphoma (DLBCL) of the elderly described as a distinct entity. In a cohort of 218 human immunodeficiency virus (HIV)-negative patients with diffuse large B-cell lymphomas, we detected EBV-DNA in 25% of whole blood (WB) samples at diagnosis. Presence and viral load in WB, mononuclear cells or plasma did not predict the presence of EBV in the tumor biopsy. Positive Hepatitis C virus (HCV) serology was associated with a higher frequency of EBV in WB. Patients with EBV-DNA in WB had a significantly shorter progression-free (p = 0.02) and overall survival (p = 0.05) after immunochemotherapy with R-CHOP (Rituximab, Cyclophosphamide, Doxorubicin, Vincristine, Prednisolone). We conclude that detection of EBV in WB is not a surrogate marker for EBV-association in diffuse large B-cell lymphoma, however it associates with worse outcome.
AB - An association between Epstein-Barr Virus (EBV) infection and lymphoproliferative diseases has been reported with EBV + diffuse large B cell-lymphoma (DLBCL) of the elderly described as a distinct entity. In a cohort of 218 human immunodeficiency virus (HIV)-negative patients with diffuse large B-cell lymphomas, we detected EBV-DNA in 25% of whole blood (WB) samples at diagnosis. Presence and viral load in WB, mononuclear cells or plasma did not predict the presence of EBV in the tumor biopsy. Positive Hepatitis C virus (HCV) serology was associated with a higher frequency of EBV in WB. Patients with EBV-DNA in WB had a significantly shorter progression-free (p = 0.02) and overall survival (p = 0.05) after immunochemotherapy with R-CHOP (Rituximab, Cyclophosphamide, Doxorubicin, Vincristine, Prednisolone). We conclude that detection of EBV in WB is not a surrogate marker for EBV-association in diffuse large B-cell lymphoma, however it associates with worse outcome.
KW - Diffuse large B-cell lymphoma
KW - EBV
KW - prognosis
KW - Diffuse large B-cell lymphoma
KW - EBV
KW - prognosis
UR - https://publicatt.unicatt.it/handle/10807/87113
UR - https://www.scopus.com/inward/citedby.uri?partnerID=HzOxMe3b&scp=84945237066&origin=inward
UR - https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=84945237066&origin=inward
U2 - 10.3109/10428194.2015.1072766
DO - 10.3109/10428194.2015.1072766
M3 - Article
SN - 1042-8194
VL - 57
SP - 628
EP - 634
JO - LEUKEMIA & LYMPHOMA
JF - LEUKEMIA & LYMPHOMA
IS - 3
ER -
