What is the role of spatial processing in the decline of episodic memory in Alzheimer's disease? The "mental frame syncing" hypothesis

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24 Citazioni (Scopus)

Abstract

The current theories on episodic memory suggest a crucial role of spatial processing for an effective retrieval. For a successful episodic recall, the long-term allocentric scene has to be translated into an egocentric scene. Here, we argue that a crucial role for an episodic retrieval is played by a "mental frame syncing" between two kinds of allocentric representations. This neurocognitive process allows an effective retrieval of our past experiences by synchronizing the allocentric view-point independent representation with the allocentric view-point dependent representation. If the "mental frame syncing" stops, even momentarily, it is difficult to reconstruct a coherent spatial scaffold upon which to effectively retrieve our previous events within an egocentric perspective. This is what apparently happens in Alzheimer's disease: a break in the "mental frame syncing" between these two kinds of allocentric representations, underpinned by damage to the hippocampus, may contribute significantly to the early deficit in episodic memory.
Lingua originaleEnglish
pagine (da-a)33-33
Numero di pagine1
RivistaFrontiers in Aging Neuroscience
Volume6
DOI
Stato di pubblicazionePubblicato - 2014

Keywords

  • Alzheimer’s disease
  • allocentric frame of reference
  • egocentric frame of reference
  • episodic memory
  • spatial cognition

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