Vitamin D Levels in Active TB, Latent TB, Non-TB Pneumonia and Healthy Children: A Prospective Observational Study

Michela Sali, Giovanni Delogu, Piero Valentini, Danilo Buonsenso, Davide Pata, Enrico Masiello, Gilda Salerno

Risultato della ricerca: Contributo in rivistaArticolo in rivista

7 Citazioni (Scopus)

Abstract

BACKGROUND: Growing evidence suggests that vitamin D deficiency might be implicated in the development of active tuberculosis (TB). We evaluated vitamin D levels in children with active TB compared to children with latent TB infection (LTBI), non-TB pneumonia (NTBP) and healthy controls to determine if there was a difference. METHODS: In this prospective study, vitamin D levels were measured and compared between the four groups and adjusted for age, ethnicity, gender and season of sample collection. RESULTS: Fifty-seven children were included: 24.6% active TB, 28.1% LTBI, 22.8% NPTB and 24.6% healthy controls. 36.8% of all children tested had an insufficient or deficient vitamin D level. Vitamin D level was significantly lower in active TB compared to other groups (p = 0.004). CONCLUSIONS: Our study showed a correlation between hypovitaminosis D and active pulmonary TB.
Lingua originaleEnglish
pagine (da-a)337-347
Numero di pagine11
RivistaFetal and Pediatric Pathology
Volume37
DOI
Stato di pubblicazionePubblicato - 2018

Keywords

  • Case-Control Studies
  • Child
  • Child, Preschool
  • Female
  • Humans
  • Infant
  • Infant, Newborn
  • Latent Tuberculosis
  • Male
  • Pneumonia
  • Tuberculosis
  • Vitamin D
  • Vitamin D Deficiency
  • latent TB infection
  • pneumonia
  • tuberculosis
  • vitamin D

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