TY - JOUR
T1 - Vitamin D Intake and the Risk of Incident Kidney Stones
AU - Ferraro, Pietro Manuel
AU - Taylor, Eric N.
AU - Gambaro, Giovanni
AU - Curhan, Gary C.
PY - 2017
Y1 - 2017
N2 - Purpose Kidney stones are a common and painful condition. Longitudinal prospective studies on the association between the intake of vitamin D and the risk of incident kidney stones are lacking. Materials and Methods We performed a prospective analysis of 193,551 participants in the Health Professionals Follow-up Study and Nurses’ Health Study I and II. Participants were divided into categories of total (less than 100, 100 to 199, 200 to 399, 400 to 599, 600 to 999, 1,000 IU per day or greater) and supplemental (none, less than 400, 400 to 599, 600 to 999, 1,000 IU per day or greater) vitamin D intake. During a followup of 3,316,846 person-years there were 6,576 incident kidney stone events. Cox proportional hazards regression models were adjusted for age, body mass index, comorbidities, use of medications and intake of other nutrients. Results After multivariate adjustment there was no statistically significant association between vitamin D intake and risk of stones in the HPFS (HR for 1,000 or greater vs less than 100 IU per day 1.08, 95% CI 0.80, 1.47, p for trend = 0.92) and the NHS I (HR 0.99, 95% CI 0.73, 1.35, p for trend = 0.70), whereas there was a suggestion of a higher risk in the NHS II (HR 1.18, 95% CI 0.94, 1.48, p for trend = 0.02). Similar results were found for supplemental vitamin D intake. Conclusions Vitamin D intake in typical amounts was not statistically associated with risk of kidney stone formation, although higher risk with higher doses than those studied here cannot be excluded.
AB - Purpose Kidney stones are a common and painful condition. Longitudinal prospective studies on the association between the intake of vitamin D and the risk of incident kidney stones are lacking. Materials and Methods We performed a prospective analysis of 193,551 participants in the Health Professionals Follow-up Study and Nurses’ Health Study I and II. Participants were divided into categories of total (less than 100, 100 to 199, 200 to 399, 400 to 599, 600 to 999, 1,000 IU per day or greater) and supplemental (none, less than 400, 400 to 599, 600 to 999, 1,000 IU per day or greater) vitamin D intake. During a followup of 3,316,846 person-years there were 6,576 incident kidney stone events. Cox proportional hazards regression models were adjusted for age, body mass index, comorbidities, use of medications and intake of other nutrients. Results After multivariate adjustment there was no statistically significant association between vitamin D intake and risk of stones in the HPFS (HR for 1,000 or greater vs less than 100 IU per day 1.08, 95% CI 0.80, 1.47, p for trend = 0.92) and the NHS I (HR 0.99, 95% CI 0.73, 1.35, p for trend = 0.70), whereas there was a suggestion of a higher risk in the NHS II (HR 1.18, 95% CI 0.94, 1.48, p for trend = 0.02). Similar results were found for supplemental vitamin D intake. Conclusions Vitamin D intake in typical amounts was not statistically associated with risk of kidney stone formation, although higher risk with higher doses than those studied here cannot be excluded.
KW - Urology
KW - cohort studies
KW - diet
KW - food and nutrition
KW - urolithiasis
KW - vitamin D
KW - Urology
KW - cohort studies
KW - diet
KW - food and nutrition
KW - urolithiasis
KW - vitamin D
UR - http://hdl.handle.net/10807/93201
UR - http://www.sciencedirect.com/science?_ob=publication
U2 - 10.1016/j.juro.2016.08.084
DO - 10.1016/j.juro.2016.08.084
M3 - Article
SN - 0022-5347
VL - 197
SP - 405
EP - 410
JO - Journal of Urology
JF - Journal of Urology
ER -