Vitamin D in the development and progression of alzheimer’s disease: implications for clinical management

Francesco Panza, Maddalena La Montagna, Luisa Lampignano, Roberta Zupo, Ilaria Bortone, Fabio Castellana, Rodolfo Sardone, Luisa Borraccino, Vittorio Dibello, Emanuela Resta, Mario Altamura, Antonio Daniele, Madia Lozupone

Risultato della ricerca: Contributo in rivistaArticolo in rivista

1 Citazioni (Scopus)


Introduction: Although the pathophysiological bases of Alzheimer’s disease (AD) remain incompletely understood and disease-modifying therapies are not available, intervention on modifiable risk factors is warranted. Research on nutrition and dietary components is challenging and controversies still persist about the role of micro- and macronutrients and health outcomes in dementia. Importantly, results of preclinical investigations have shown that vitamin D triggers different neural pathways that may be protective against these neurodegenerative mechanisms, including the deposition of amyloid plaques, inflammatory processes, neurofibrillary degeneration, glutamatergic excitotoxicity, excessive intraneuronal calcium influx, and oxidative stress, although its relationship with AD still needs to be fully understood. Areas covered: The authors analyzed the recent evidence about the effects of vitamin D insufficiency on AD and the role of supplementation. Expert opinion: Both insufficient (25–49.9 ng/ml) and deficient levels (<25 ng/ml) of vitamin D may contribute to an increased susceptibility to AD. However, further well-designed prospective studies are needed for a better understanding of the involvement of low vitamin D concentrations in the AD natural history. Randomized clinical trials will also be necessary to address the issue of causality and determine whether vitamin D supplementation may be effective for the prevention or treatment of AD.
Lingua originaleEnglish
pagine (da-a)1-15-15
RivistaExpert Review of Neurotherapeutics
Stato di pubblicazionePubblicato - 2021


  • Calcitriol
  • alzheimer’s disease
  • amyloid-β clearance
  • mild cognitive impairment
  • neurosteroid
  • neurotrophic factor
  • nutritional frailty
  • supplementation


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