Vitamin D deficiency: a new risk factor for type 2 diabetes?

Teresa Mezza, Giovanna Muscogiuri, Gianpio Sorice, Annamaria Prioletta, Enrica Salomone, Alfredo Pontecorvi, Andrea Giaccari

Risultato della ricerca: Contributo in rivistaArticolo in rivistapeer review

78 Citazioni (Scopus)


Recent compelling evidence suggests a role of vitamin D deficiency in the pathogenesis of insulin resistance and insulin secretion derangements, with a consequent possible interference with type 2 diabetes mellitus. The mechanism of this link is incompletely understood. In fact, vitamin D deficiency is usually detected in obesity in which insulin resistance is also a common finding. The coexistence of insulin resistance and vitamin D deficiency has generated several hypotheses. Some cross-sectional and prospective studies have suggested that vitamin D deficiency may play a role in worsening insulin resistance; others have identified obesity as a risk factor predisposing individuals to exhibit both vitamin D deficiency and insulin resistance. The available data from intervention studies are largely confounded, and inadequate considerations of seasonal effects on 25(OH)D concentrations are also a common design flaw in many studies. On the contrary, there is strong evidence that obesity might cause both vitamin D deficiency and insulin resistance, leaving open the possibility that vitamin D and diabetes are not related at all. Although it might seem premature to draw firm conclusions on the role of vitamin D supplementation in reducing insulin resistance and preventing type 2 diabetes, this manuscript will review the circumstances leading to vitamin D deficiency and how such a deficiency can eventually independently affect insulin sensitivity.
Lingua originaleEnglish
pagine (da-a)337-348
Numero di pagine12
RivistaAnnals of Nutrition and Metabolism
Stato di pubblicazionePubblicato - 2012


  • diabete mellito
  • diabetes
  • insulin resistance
  • insulino-resistenza
  • obesity
  • obesità
  • vitamin D
  • vitamina D


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