Vitamin D and Histological Features of Breast Cancer: Preliminary Data from an Observational Retrospective Italian Study

Giovanni Scambia, Gianluca Franceschini, Antonella Capozzi, Roberto Sorge

Risultato della ricerca: Contributo in rivistaArticolo in rivista

Abstract

Background: Vitamin D (vitD) may be involved in different extraskeletal conditions as well as skeletal muscle diseases. It has been hypothesized that, at least in part, a low level of vitD could contribute to facilitating cancer development. Breast cancer (BC) seems to be associated with low levels of vitD. Materials and methods: This was an observational retrospective evaluation of 87 women (mean age: 54 ± 12 years old) who underwent surgery for the treatment of BC. Our main purpose was to correlate the types of BC and the levels of vitD. Results: A positive significant correlation (R > 0.7) was found between non-invasive carcinoma in situ and 25(OH)D levels and age (R = 0.82, p < 0.05). A positive, but nonsignificant, correlation was reported between invasive ductal carcinoma and 25(OH)D and age (R = 0.45, p > 0.05). A negative but nonsignificant correlation was found between invasive lobular carcinoma and 25(OH)D and age (R = 0.24, p > 0.05). Discussion and Conclusions: We did not find a significant relationship between vitD and BC subtypes. Considering the positive significant correlation between vitD levels and age for in situ BC, although preliminary, our results seem to suggest a possible role of vitD in in situ BC. However, these findings need to be confirmed in larger studies.
Lingua originaleEnglish
pagine (da-a)1-8
Numero di pagine8
RivistaJournal of Personalized Medicine
Volume12
DOI
Stato di pubblicazionePubblicato - 2022

Keywords

  • breast cancer
  • ductal breast cancer
  • histology
  • in situ breast cancer
  • lobular breast cancer
  • vitamin D

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