Vitamin D and colorectal cancer: Chemopreventive perspectives through the gut microbiota and the immune system

Emanuele Rinninella, Maria Cristina Mele, Antonio Gasbarrini, Pauline Celine Raoul, Marco Cintoni

Risultato della ricerca: Contributo in rivistaArticolo in rivista

Abstract

Vitamin D and its receptor are involved in health and diseases through multiple mechanisms including the immune system and gut microbiota modulations. Gut microbiota variations have huge implications in intestinal and extra-intestinal disorders such as colorectal cancer (CRC). This review highlights the preventive role of vitamin D in colorectal tumorigenesis through the effects on the immune system and gut microbiota modulation. The different associations between vitamin D, gut microbial homeostasis, immune system, and CRC, are dissected. Vitamin D is supposed to exert several chemopreventive effects on CRC including direct antineoplastic mechanisms, the effects on the immune system, and gut microbiota modulation. Large clinical studies with a randomized design, are required to confirm the role of vitamin D in CRC, confirming its key role in the complex interplay between the gut immune system and microbiota.
Lingua originaleEnglish
pagine (da-a)1-9
Numero di pagine9
RivistaBioFactors
DOI
Stato di pubblicazionePubblicato - 2021

Keywords

  • colorectal cancer
  • gut microbiota
  • vitamin D
  • inflammation
  • immune system

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