Vitamin D and age-related macular degeneration

Angelo Maria Minnella, Alfredo Garcia Layana, Gerhard Garhöfer, Tariq Aslam, Frank G. Holz, Anita Leys, Rufino Silva, Cécile Delcourt, Eric Souied, Johanna M. Seddon

Risultato della ricerca: Contributo in rivistaArticolo in rivista

17 Citazioni (Scopus)

Abstract

In recent years, the relationship between vitamin D and health has received growing attention from the scientific and medical communities. Vitamin D deficiencies have been repeatedly associated with various acute and chronic diseases, including age-related macular degeneration (AMD). Its active metabolite, 1α,25-dihydoxy vitamin D, acts as a modulator of cell proliferation, differentiation and apoptosis, and cumulative data from experimental and observational studies suggest that relatively a lower vitamin D status could be a potential risk factor for the development of early and/or late AMD. Herein, we made a narrative review of the mechanisms linking a potential role of vitamin D with the current concepts of AMD pathophysiology.
Lingua originaleEnglish
pagine (da-a)1120-1134
Numero di pagine15
RivistaNutrients
Volume9
DOI
Stato di pubblicazionePubblicato - 2017

Keywords

  • Age-related macular degeneration
  • Angiogenesis
  • Animals
  • Biomarkers
  • Humans
  • Inflammation
  • Macular Degeneration
  • Prognosis
  • Risk Assessment
  • Risk Factors
  • Vitamin D
  • Vitamin D Deficiency

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