Visual pathway neurodegeneration winged by mitochondrial dysfunction.

Barbara Tavazzi, Angela Maria Amorini, Giacomo Lazzarino, Giacomo Lazzarino, Axel Petzold, Philip G. Nijland, Lisanne J. Balk, Mike P. Wattjes, Claudio Gasperini, Paul Van Der Valk, Giuseppe Lazzarino, Jack Van Horssen

Risultato della ricerca: Contributo in rivistaArticolo in rivistapeer review

10 Citazioni (Scopus)

Abstract

dysfunction to neurodegeneration in multiple sclerosis (MS). A visual pathway model void of MS lesions was chosen in order to exclude neurodegeneration secondary to lesion related axonotmesis. Methods: A single-centre cohort study (230 MS patients, 63 controls). Spectral domain optical coherence tomography of the retina, 3T magnetic resonance imaging of the brain, spectrophotometric assessment of serum lactate levels. Postmortem immunohistochemistry. Results: The visual pathway was void of MS lesions in 31 patients and 31 age-matched controls. Serum lactate was higher in MS compared to controls (P = 0.029). High serum lactate was structurally related to atrophy of the retinal nerve fiber layer at the optic disc (P = 0.041), macula (P = 0.025), and the macular gan- glion cell complex (P = 0.041). High serum lactate was functionally related to color vision (P < 0.01), Expanded Disability Status Scale score (P = 0.041), Guy’s Neurological disability score (P = 0.037), MS walking scale (P = 0.009), upper limb motor function (R = 0.53, P = 0.002). Immunohistochemistry dem- onstrated increased astrocytic expression of a key lactate generating enzyme in MS lesions as well as profound vascular expression of monocarboxylate trans- porter-1, which is involved in lactate transport. Interpretation: This study provides structural, functional, and translational evidence for visual pathway neurodegeneration in MS related to mitochondrial dysfunction.
Lingua originaleEnglish
pagine (da-a)1-11
Numero di pagine11
RivistaAnnals of Clinical and Translational Neurology
Volume2015
DOI
Stato di pubblicazionePubblicato - 2014

Keywords

  • mitochondrial dysfunction
  • multiple sclerosis
  • visual neurodegeneration

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