TY - JOUR
T1 - Viral Hepatitides, Inflammation and Tumour Microenvironment
AU - Timperi, Eleonora
AU - Barnaba, Vincenzo
PY - 2020
Y1 - 2020
N2 - In this chapter, we discuss the role of hepatitis B virus (HBV) and hepatitis C virus (HCV) infections in the establishment of hepatocellular carcinoma (HCC), highlighting the key role of the multiple, non-mutually exclusive, pathways involved in the modulation of immune responses and in the orchestration of a chronic low-level inflammation state favouring HCC development. In particular, we discuss (i) HCC as a classical paradigm of inflammation-linked cancer; (ii) the role of the most relevant inflammatory cytokines involved (i.e. IL-6, TNF-α, IL-18, IL-1β, TGF-β IL-10); (iii) the role of T cell exhaustion by immune checkpoints; (iv) the role of the Wnt3a/β-catenin signalling pathway and (v) the role of different subsets of suppressor cells.
AB - In this chapter, we discuss the role of hepatitis B virus (HBV) and hepatitis C virus (HCV) infections in the establishment of hepatocellular carcinoma (HCC), highlighting the key role of the multiple, non-mutually exclusive, pathways involved in the modulation of immune responses and in the orchestration of a chronic low-level inflammation state favouring HCC development. In particular, we discuss (i) HCC as a classical paradigm of inflammation-linked cancer; (ii) the role of the most relevant inflammatory cytokines involved (i.e. IL-6, TNF-α, IL-18, IL-1β, TGF-β IL-10); (iii) the role of T cell exhaustion by immune checkpoints; (iv) the role of the Wnt3a/β-catenin signalling pathway and (v) the role of different subsets of suppressor cells.
KW - Chronic low-level inflammation
KW - Wnt/β-catenin
KW - HBV
KW - HCV
KW - Hepatic sentinel cells
KW - Hepatocellular carcinoma
KW - Immune checkpoint blockade
KW - Immunopathology
KW - Immunoregulatory mechanisms
KW - Liver
KW - Suppressor cells
KW - T cell exhaustion
KW - T cells
KW - Tumour microenvironment
KW - Cytokines
KW - Chronic low-level inflammation
KW - Wnt/β-catenin
KW - HBV
KW - HCV
KW - Hepatic sentinel cells
KW - Hepatocellular carcinoma
KW - Immune checkpoint blockade
KW - Immunopathology
KW - Immunoregulatory mechanisms
KW - Liver
KW - Suppressor cells
KW - T cell exhaustion
KW - T cells
KW - Tumour microenvironment
KW - Cytokines
UR - http://hdl.handle.net/10807/305307
U2 - 10.1007/978-3-030-44518-8_3
DO - 10.1007/978-3-030-44518-8_3
M3 - Article
SP - 25
EP - 43
JO - Advances in experimental medicine and biology
JF - Advances in experimental medicine and biology
ER -