Viral Hepatitides, Inflammation and Tumour Microenvironment

Eleonora Timperi, Vincenzo Barnaba

Risultato della ricerca: Contributo in rivistaArticolo in rivista

Abstract

In this chapter, we discuss the role of hepatitis B virus (HBV) and hepatitis C virus (HCV) infections in the establishment of hepatocellular carcinoma (HCC), highlighting the key role of the multiple, non-mutually exclusive, pathways involved in the modulation of immune responses and in the orchestration of a chronic low-level inflammation state favouring HCC development. In particular, we discuss (i) HCC as a classical paradigm of inflammation-linked cancer; (ii) the role of the most relevant inflammatory cytokines involved (i.e. IL-6, TNF-α, IL-18, IL-1β, TGF-β IL-10); (iii) the role of T cell exhaustion by immune checkpoints; (iv) the role of the Wnt3a/β-catenin signalling pathway and (v) the role of different subsets of suppressor cells.
Lingua originaleEnglish
pagine (da-a)25-43
Numero di pagine19
RivistaAdvances in experimental medicine and biology
DOI
Stato di pubblicazionePubblicato - 2020

Keywords

  • Chronic low-level inflammation
  • Wnt/β-catenin
  • HBV
  • HCV
  • Hepatic sentinel cells
  • Hepatocellular carcinoma
  • Immune checkpoint blockade
  • Immunopathology
  • Immunoregulatory mechanisms
  • Liver
  • Suppressor cells
  • T cell exhaustion
  • T cells
  • Tumour microenvironment
  • Cytokines

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