Abstract
Evaluation of expression of 16 PE_PGRS genes present in Mycobacterium tuberculosis under various growth conditions demonstrated constitutive expression of 7 genes, variable expression of 7 genes, and no expression of 2 genes. An inverse expression profile for genes PE_PGRS16 and PE_PGRS26 was observed to occur in macrophages and in mice infected with M. tuberculosis. Variable expression of PE_PGRS proteins could have implications for their role in the immunopathogenesis of tuberculosis.
| Lingua originale | Inglese |
|---|---|
| pagine (da-a) | 3721-3725 |
| Numero di pagine | 5 |
| Rivista | Journal of Bacteriology |
| Volume | 188 |
| DOI | |
| Stato di pubblicazione | Pubblicato - 2006 |
OSS delle Nazioni Unite
Questo processo contribuisce al raggiungimento dei seguenti obiettivi di sviluppo sostenibile
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SDG 3 Salute e benessere
Keywords
- Antigens, Bacterial
- Bacterial Proteins
- Gene Expression Regulation, Bacterial
- Genetic Variation
- Membrane Proteins
- Mycobacterium tuberculosis
- Protein Isoforms
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