Variable expression patterns of Mycobacterium tuberculosis PE_PGRS genes: evidence that PE_PGRS16 and PE_PGRS26 are inversely regulated in vivo

V Dheenadhayalan; Giovanni Delogu; Maurizio Sanguinetti; Giovanni Fadda; Mj Brennan

doi:10.1128/JB.188.10.3721-3725.2006

Variable expression patterns of Mycobacterium tuberculosis PE_PGRS genes: evidence that PE_PGRS16 and PE_PGRS26 are inversely regulated in vivo

V Dheenadhayalan, Giovanni Delogu, Maurizio Sanguinetti, Giovanni Fadda, Mj Brennan

Risultato della ricerca: Contributo in rivista › Articolo in rivista › peer review

51 Citazioni (Scopus)

Abstract

Evaluation of expression of 16 PE_PGRS genes present in Mycobacterium tuberculosis under various growth conditions demonstrated constitutive expression of 7 genes, variable expression of 7 genes, and no expression of 2 genes. An inverse expression profile for genes PE_PGRS16 and PE_PGRS26 was observed to occur in macrophages and in mice infected with M. tuberculosis. Variable expression of PE_PGRS proteins could have implications for their role in the immunopathogenesis of tuberculosis.

Lingua originale	English
pagine (da-a)	3721-3725
Numero di pagine	5
Rivista	Journal of Bacteriology
Volume	188
DOI	https://doi.org/10.1128/JB.188.10.3721-3725.2006
Stato di pubblicazione	Pubblicato - 2006

Keywords

Antigens, Bacterial
Bacterial Proteins
Gene Expression Regulation, Bacterial
Genetic Variation
Membrane Proteins
Mycobacterium tuberculosis
Protein Isoforms

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abstract = "Evaluation of expression of 16 PE_PGRS genes present in Mycobacterium tuberculosis under various growth conditions demonstrated constitutive expression of 7 genes, variable expression of 7 genes, and no expression of 2 genes. An inverse expression profile for genes PE_PGRS16 and PE_PGRS26 was observed to occur in macrophages and in mice infected with M. tuberculosis. Variable expression of PE_PGRS proteins could have implications for their role in the immunopathogenesis of tuberculosis.",

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author = "V Dheenadhayalan and Giovanni Delogu and Maurizio Sanguinetti and Giovanni Fadda and Mj Brennan",

year = "2006",

doi = "10.1128/JB.188.10.3721-3725.2006",

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T1 - Variable expression patterns of Mycobacterium tuberculosis PE_PGRS genes: evidence that PE_PGRS16 and PE_PGRS26 are inversely regulated in vivo

AU - Dheenadhayalan, V

AU - Delogu, Giovanni

AU - Sanguinetti, Maurizio

AU - Fadda, Giovanni

AU - Brennan, Mj

PY - 2006

Y1 - 2006

N2 - Evaluation of expression of 16 PE_PGRS genes present in Mycobacterium tuberculosis under various growth conditions demonstrated constitutive expression of 7 genes, variable expression of 7 genes, and no expression of 2 genes. An inverse expression profile for genes PE_PGRS16 and PE_PGRS26 was observed to occur in macrophages and in mice infected with M. tuberculosis. Variable expression of PE_PGRS proteins could have implications for their role in the immunopathogenesis of tuberculosis.

AB - Evaluation of expression of 16 PE_PGRS genes present in Mycobacterium tuberculosis under various growth conditions demonstrated constitutive expression of 7 genes, variable expression of 7 genes, and no expression of 2 genes. An inverse expression profile for genes PE_PGRS16 and PE_PGRS26 was observed to occur in macrophages and in mice infected with M. tuberculosis. Variable expression of PE_PGRS proteins could have implications for their role in the immunopathogenesis of tuberculosis.

KW - Antigens, Bacterial

KW - Bacterial Proteins

KW - Gene Expression Regulation, Bacterial

KW - Genetic Variation

KW - Membrane Proteins

KW - Mycobacterium tuberculosis

KW - Protein Isoforms

KW - Antigens, Bacterial

KW - Bacterial Proteins

KW - Gene Expression Regulation, Bacterial

KW - Genetic Variation

KW - Membrane Proteins

KW - Mycobacterium tuberculosis

KW - Protein Isoforms

UR - http://hdl.handle.net/10807/6593

U2 - 10.1128/JB.188.10.3721-3725.2006

DO - 10.1128/JB.188.10.3721-3725.2006

M3 - Article

SN - 0021-9193

VL - 188

SP - 3721

EP - 3725

JO - Journal of Bacteriology

JF - Journal of Bacteriology

ER -

Variable expression patterns of Mycobacterium tuberculosis PE_PGRS genes: evidence that PE_PGRS16 and PE_PGRS26 are inversely regulated in vivo

Abstract

Keywords

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