Variable expression patterns of Mycobacterium tuberculosis PE_PGRS genes: evidence that PE_PGRS16 and PE_PGRS26 are inversely regulated in vivo

Giovanni Delogu, Maurizio Sanguinetti, Giovanni Fadda, V Dheenadhayalan, Mj Brennan

Risultato della ricerca: Contributo in rivistaArticolo in rivistapeer review

51 Citazioni (Scopus)

Abstract

Evaluation of expression of 16 PE_PGRS genes present in Mycobacterium tuberculosis under various growth conditions demonstrated constitutive expression of 7 genes, variable expression of 7 genes, and no expression of 2 genes. An inverse expression profile for genes PE_PGRS16 and PE_PGRS26 was observed to occur in macrophages and in mice infected with M. tuberculosis. Variable expression of PE_PGRS proteins could have implications for their role in the immunopathogenesis of tuberculosis.
Lingua originaleEnglish
pagine (da-a)3721-3725
Numero di pagine5
RivistaJournal of Bacteriology
Volume188
DOI
Stato di pubblicazionePubblicato - 2006

Keywords

  • Antigens, Bacterial
  • Bacterial Proteins
  • Gene Expression Regulation, Bacterial
  • Genetic Variation
  • Membrane Proteins
  • Mycobacterium tuberculosis
  • Protein Isoforms

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