Value of serum nonceruloplasmin copper for prediction of mild cognitive impairment conversion to Alzheimer disease

Paolo Maria Rossini, Rosanna Squitti, Roberta Ghidoni, Mariacristina Siotto, Mariacarla Ventriglia, Luisa Benussi, Anna Paterlini, Mariachiara Magri, Giuliano Binetti, Emanuele Cassetta, Deborah Caprara, Fabrizio Vernieri, Patrizio Pasqualetti

Risultato della ricerca: Contributo in rivistaArticolo in rivista

71 Citazioni (Scopus)

Abstract

Meta-analyses show that nonbound ceruloplasmin (non-Cp) copper (also known as free or labile copper) in serum is higher in patients with Alzheimer disease (AD). It differentiates subjects with mild cognitive impairment (MCI) from healthy controls. However, a longitudinal study on an MCI cohort has not yet been performed to assess the accuracy of non-Cp copper for the prediction of conversion from MCI to AD during a long-term follow-up.
Lingua originaleEnglish
pagine (da-a)574-580
Numero di pagine7
RivistaAnnals of Neurology
Volume75
DOI
Stato di pubblicazionePubblicato - 2014

Keywords

  • Alzheimer Disease
  • Apolipoprotein E4
  • Ceruloplasmin
  • Cognition Disorders
  • Copper
  • Disease Progression
  • Female
  • Humans
  • Longitudinal Studies
  • Male
  • Neuropsychological Tests
  • Predictive Value of Tests
  • Probability
  • Risk Factors

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