[Value of carbon in the thrombogenicity of cardiovascular prostheses]

Massimo Massetti, G Babatasi, L Bara, F Galateau, M. F Bloch, F Boulakia Cohen, A Khayat, M. M. Samama

Risultato della ricerca: Contributo in rivistaArticolo in rivista

Abstract

Forty five Carbon-lined (CL) and 45 Standard (ST) 4 mm internal diameter polytetrafluoroethylene (PTFE) grafts were implanted as aortic interpositions in 90 New Zealand rabbits. In a pilot study of 20 animals, 10 CL and 10 ST grafts were used to develop microsurgical techniques, then 60 grafts were placed in 60 rabbits with lower morbidity. The 2-hour graft patency (Doppler study, Transonic flow probe and 8 mHZ) showed a better patency rate in the CL group (93% versus 80%). In 10 animals, platelet accumulation was investigated in vivo using scintigraphy after injection of autologous platelets labeled with Indium111. In vitro, radioactivity counting of the explanted midgrafts sections at 2 hours revealed a 6-fold higher activity in ST grafts (6.60 +/- 1.98 x 103 platelets/mm2 versus 0.82 +/- 0.25 x 103 platelets/mm2; p < 0.05). Light microscopy found platelet and fibrin deposition (PFD) in nearly all ST grafts, whereas PFD were found in only 13% of the CL grafts corresponding to those thrombosed grafts (chi2:61.117; p < 0.001). Carbon-lining decreases platelet accumulation on PTFE grafts and the rabbit aortic interposition appears to constitute a quantitative and reproducible model for investigation of antithrombotic drugs.
Titolo tradotto del contributo[Autom. eng. transl.] [Value of carbon in the thrombogenicity of cardiovascular prostheses]
Lingua originaleFrench
pagine (da-a)7-14
Numero di pagine8
RivistaANNALES DE CARDIOLOGIE ET D'ANGEIOLOGIE.
Volume46
Stato di pubblicazionePubblicato - 1997

Keywords

  • Animals
  • Blood Platelets
  • Blood Vessel Prosthesis
  • Carbon
  • Graft Occlusion, Vascular
  • Indium Radioisotopes
  • Microsurgery
  • Polytetrafluoroethylene
  • Postoperative Complications
  • Rabbits
  • Radionuclide Imaging
  • Thrombosis
  • Time Factors

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