Vaccine effectiveness against severe laboratory-confirmed influenza in children: results of two consecutive seasons in Italy.

Nadia Mores, Antonio Chiaretti, Giovanni Delogu, Michela Sali, Costantino Romagnoli, Adele Compagnone, Riccardo Riccardi, Francesca Menniti-Ippolito, Roberto Da Cas, Giuseppe Traversa, Carmela Santuccio, Patrizia Felicetti, Loriana Tartaglia, Francesco Trotta, Pasquale Di Pietro, Paola Barabino, Salvatore Renna, Laura Riceputi, Pier-Angelo Tovo, Clara GabianoAntonio Urbino, Luca Baroero, Daniele Le Serre, Silvia Virano, Giorgio Perilongo, Marco Daverio, Elisa Gnoato, Michela Maretti, Beatrice Galeazzo, Giulia Rubin, Stefania Scanferla, Liviana Da Dalt, Chiara Stefani, Claudia Zerbinati, Elena Chiappini, Sara Sollai, Maurizio De Martino, Francesco Mannelli, Sabrina Becciani, Martina Giacalone, Simona Montano, Giulia Remaschi, Alessia Stival, Mario Furbetta, Piera Abate, Ilaria Leonardi, Nicola Pirozzi, Umberto Raucci, Antonino Reale, Rossella Rossi, Cristina Russo, Livia Mancinelli, Onori Manuela, Concato Carlo, Vincenzo Tipo, Michele Dinardo, Fabiana Auricchio, Teodoro Polimeno, Giuseppe Sodano, Alessandra Maccariello, Concita Rafaniello, Fortunata Fucà, Eleonora Di Rosa, Domenica Altavilla, Anna Mecchio, Teresa Arrigo

Risultato della ricerca: Contributo in rivistaArticolo in rivistapeer review

12 Citazioni (Scopus)

Abstract

OBJECTIVE: To evaluate the effectiveness of seasonal influenza vaccine in preventing Emergency Department (ED) visits and hospitalisations for influenza like illness (ILI) in children. METHODS: We conducted a test negative case-control study during the 2011-2012 and 2012-2013 influenza seasons. Eleven paediatric hospital/wards in seven Italian regions participated in the study. Consecutive children visiting the ED with an ILI, as diagnosed by the doctor according to the European Centre for Disease Control case definition, were eligible for the study. Data were collected from trained pharmacists/physicians by interviewing parents during the ED visit (or hospital admission) of their children. An influenza microbiological test (RT-PCR) was carried out in all children. RESULTS: Seven-hundred and four children, from 6 months to 16 years of age, were enrolled: 262 children tested positive for one of the influenza viruses (cases) and 442 tested negative (controls). Cases were older than controls (median age 46 vs. 29 months), though with a similar prevalence of chronic conditions. Only 25 children (4%) were vaccinated in the study period. The overall age-adjusted vaccine effectiveness (VE) was 38% (95% confidence interval -52% to 75%). A higher VE was estimated for hospitalised children (53%; 95% confidence interval -45% to 85%). DISCUSSION: This study supports the effectiveness of the seasonal influenza vaccine in preventing visits to the EDs and hospitalisations for ILI in children, although the estimates were not statistically significant and with wide confidence intervals. Future systematic reviews of available data will provide more robust evidence for recommending influenza vaccination in children.
Lingua originaleEnglish
pagine (da-a)4466-4470
Numero di pagine5
RivistaVACCINE
Volume2014
DOI
Stato di pubblicazionePubblicato - 2014

Keywords

  • Vaccine effectiveness
  • influenza in children

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