Vaccination of Lactating Dairy Cows for the Prevention of Aflatoxin B-1 Carry Over in Milk

L Polonelli; L Giovati; W Magliani; Stefania Conti; S Sforza; A Calabretta; C Casoli; P Ronzi; Ester Grilli; Antonio Gallo; Francesco Masoero; Gianfranco Piva

doi:10.1371/journal.pone.0026777

Vaccination of Lactating Dairy Cows for the Prevention of Aflatoxin B-1 Carry Over in Milk

L Polonelli^*, L Giovati, W Magliani, Stefania Conti, S Sforza, A Calabretta, C Casoli, P Ronzi, Ester Grilli, Antonio Gallo, Francesco Masoero, Gianfranco Piva

^*Autore corrispondente per questo lavoro

Risultato della ricerca: Contributo in rivista › Articolo › peer review

18 Citazioni (Scopus)

Abstract

The potential of anaflatoxin B1 (AnAFB1) conjugated to keyhole limpet hemocyanin (KLH) as a vaccine (AnAFB1-KLH) in\r\ncontrolling the carry over of the aflatoxin B1 (AFB1) metabolite aflatoxin M1 (AFM1) in cow milk is reported. AFB1 is the most\r\ncarcinogenic compound in food and foodstuffs amongst aflatoxins (AFs). AnAFB1 is AFB1 chemically modified as AFB1-1(Ocarboxymethyl)\r\noxime. In comparison to AFB1, AnAFB1 has proven to be non-toxic in vitro to human hepatocarcinoma cells\r\nand non mutagenic to Salmonella typhimurium strains. AnAFB1-KLH was used for immunization of cows proving to induce a\r\nlong lasting titer of anti-AFB1 IgG antibodies (Abs) which were cross reactive with AFB1, AFG1, and AFG2. The elicited anti-\r\nAFB1 Abs were able to hinder the secretion of AFM1 into the milk of cows continuously fed with AFB1. Vaccination of\r\nlactating animals with conjugated AnAFB1 may represent a solution to the public hazard constituted by milk and cheese\r\ncontaminated

Lingua originale	Inglese
pagine (da-a)	1-9
Numero di pagine	9
Rivista	PLoS One
Volume	6
Numero di pubblicazione	Febbraio
DOI	https://doi.org/10.1371/journal.pone.0026777
Stato di pubblicazione	Pubblicato - 2011

All Science Journal Classification (ASJC) codes

Multidisciplinare

Keywords

Lactating Dairy Cows
aflatoxin B1
vaccination

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10.1371/journal.pone.0026777

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abstract = "The potential of anaflatoxin B1 (AnAFB1) conjugated to keyhole limpet hemocyanin (KLH) as a vaccine (AnAFB1-KLH) in\textbackslash{}r\textbackslash{}ncontrolling the carry over of the aflatoxin B1 (AFB1) metabolite aflatoxin M1 (AFM1) in cow milk is reported. AFB1 is the most\textbackslash{}r\textbackslash{}ncarcinogenic compound in food and foodstuffs amongst aflatoxins (AFs). AnAFB1 is AFB1 chemically modified as AFB1-1(Ocarboxymethyl)\textbackslash{}r\textbackslash{}noxime. In comparison to AFB1, AnAFB1 has proven to be non-toxic in vitro to human hepatocarcinoma cells\textbackslash{}r\textbackslash{}nand non mutagenic to Salmonella typhimurium strains. AnAFB1-KLH was used for immunization of cows proving to induce a\textbackslash{}r\textbackslash{}nlong lasting titer of anti-AFB1 IgG antibodies (Abs) which were cross reactive with AFB1, AFG1, and AFG2. The elicited anti-\textbackslash{}r\textbackslash{}nAFB1 Abs were able to hinder the secretion of AFM1 into the milk of cows continuously fed with AFB1. Vaccination of\textbackslash{}r\textbackslash{}nlactating animals with conjugated AnAFB1 may represent a solution to the public hazard constituted by milk and cheese\textbackslash{}r\textbackslash{}ncontaminated",

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AU - Polonelli, L

AU - Giovati, L

AU - Magliani, W

AU - Conti, Stefania

AU - Sforza, S

AU - Calabretta, A

AU - Casoli, C

AU - Ronzi, P

AU - Grilli, Ester

AU - Gallo, Antonio

AU - Masoero, Francesco

AU - Piva, Gianfranco

PY - 2011

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Vaccination of Lactating Dairy Cows for the Prevention of Aflatoxin B-1 Carry Over in Milk

Abstract

All Science Journal Classification (ASJC) codes

Keywords

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