TY - JOUR
T1 - Uveal melanoma: evaluation of extrascleral
extension using thin-section MR of the eye with surface coils
AU - Tartaglione, Tommaso
AU - Pagliara, Monica Maria
AU - Sciandra, Mariacarmela
AU - Caputo, Carmela Grazia
AU - Calandrelli, Rosalinda
AU - Fabrizi, Gina
AU - Gaudino, Simona
AU - Blasi, Maria Antonietta
AU - Colosimo, Cesare
PY - 2014
Y1 - 2014
N2 - PURPOSE:
This study was done to evaluate the role of high-resolution magnetic resonance (MR) imaging with special surface coils in selecting the correct therapeutic approach (eye enucleation or follow-up) in patients with suspected extrascleral extension of uveal melanoma.
MATERIALS AND METHODS:
This prospective study involved 12 patients with suspected extrascleral extension of uveal melanoma on orbital ultrasonography. All patients were studied with thin-section MR imaging of the eye using surface coils.
RESULTS:
High-resolution MR imaging of the eye excluded extrascleral extension of disease in 8/12 patients: in 4/8 cases it revealed vascular ectasia and in the other 4/8 cases the linear hypointensity of the sclera was unbroken. Seven of these eight patients were followed up by ultrasound, which showed stability of melanoma for at least 2 years, while the last patient underwent enucleation, and the histological examination confirmed the MR diagnosis. In 4/12 patients, high-resolution MR suggested a diagnosis of extrascleral extension of melanoma, which was confirmed at histological examination after enucleation.
CONCLUSION:
High-resolution MR imaging of the eye with surface coils allowed us to evaluate extrascleral extension of uveal melanoma and choose the correct therapeutic approach, avoiding unnecessary enucleation in 7/12 patients.
AB - PURPOSE:
This study was done to evaluate the role of high-resolution magnetic resonance (MR) imaging with special surface coils in selecting the correct therapeutic approach (eye enucleation or follow-up) in patients with suspected extrascleral extension of uveal melanoma.
MATERIALS AND METHODS:
This prospective study involved 12 patients with suspected extrascleral extension of uveal melanoma on orbital ultrasonography. All patients were studied with thin-section MR imaging of the eye using surface coils.
RESULTS:
High-resolution MR imaging of the eye excluded extrascleral extension of disease in 8/12 patients: in 4/8 cases it revealed vascular ectasia and in the other 4/8 cases the linear hypointensity of the sclera was unbroken. Seven of these eight patients were followed up by ultrasound, which showed stability of melanoma for at least 2 years, while the last patient underwent enucleation, and the histological examination confirmed the MR diagnosis. In 4/12 patients, high-resolution MR suggested a diagnosis of extrascleral extension of melanoma, which was confirmed at histological examination after enucleation.
CONCLUSION:
High-resolution MR imaging of the eye with surface coils allowed us to evaluate extrascleral extension of uveal melanoma and choose the correct therapeutic approach, avoiding unnecessary enucleation in 7/12 patients.
KW - MR-EYE
KW - Melanoma Uveale
KW - RM occhio
KW - Uveal Melanoma
KW - MR-EYE
KW - Melanoma Uveale
KW - RM occhio
KW - Uveal Melanoma
UR - http://hdl.handle.net/10807/62693
U2 - 10.1007/s11547-014-0388-x
DO - 10.1007/s11547-014-0388-x
M3 - Article
SN - 0033-8362
VL - 2014
SP - 775
EP - 783
JO - LA RADIOLOGIA MEDICA
JF - LA RADIOLOGIA MEDICA
ER -