Using peripheral immune-inflammatory blood markers in tumors treated with immune checkpoint inhibitors: An INVIDIa-2 study sub-analysis

Shobana Anpalakhan; Alessio Signori; Alessio Cortellini; Elena Verzoni; Raffaele Giusti; Giuseppe Aprile; Paola Ermacora; Annamaria Catino; Stefania Pipitone; Marilena Di Napoli; Vieri Scotti; Francesca Mazzoni; Pamela F. Guglielmini; Antonello Veccia; Marco Maruzzo; Giovanni Schinzari; Chiara Casadei; Francesco Grossi; Mimma Rizzo; Vincenzo Montesarchio; Francesco Verderame; Manlio Mencoboni; Fable Zustovich; Lucia Fratino; Caterina Accettura; Saverio Cinieri; Carlo Alberto Tondini; Andrea Camerini; Maria Chiara Banzi; Mariella Sorarù; Paolo Andrea Zucali; Francesca Vignani; Serena Ricciardi; Antonio Russo; Agnese Cosenza; Massimo Di Maio; Ugo De Giorgi; Sandro Pignata; Diana Giannarelli; Carmine Pinto; Sebastiano Buti; Giuseppe Fornarini; Sara Elena Rebuzzi; Pasquale Rescigno; Alfredo Addeo; Giuseppe L. Banna; Melissa Bersanelli

doi:10.1016/j.isci.2023.107970

Using peripheral immune-inflammatory blood markers in tumors treated with immune checkpoint inhibitors: An INVIDIa-2 study sub-analysis

Shobana Anpalakhan, Alessio Signori, Alessio Cortellini, Elena Verzoni, Raffaele Giusti, Giuseppe Aprile, Paola Ermacora, Annamaria Catino, Stefania Pipitone, Marilena Di Napoli, Vieri Scotti, Francesca Mazzoni, Pamela F. Guglielmini, Antonello Veccia, Marco Maruzzo, Giovanni Schinzari, Chiara Casadei, Francesco Grossi, Mimma Rizzo, Vincenzo MontesarchioFrancesco Verderame, Manlio Mencoboni, Fable Zustovich, Lucia Fratino, Caterina Accettura, Saverio Cinieri, Carlo Alberto Tondini, Andrea Camerini, Maria Chiara Banzi, Mariella Sorarù, Paolo Andrea Zucali, Francesca Vignani, Serena Ricciardi, Antonio Russo, Agnese Cosenza, Massimo Di Maio, Ugo De Giorgi, Sandro Pignata, Diana Giannarelli, Carmine Pinto, Sebastiano Buti, Giuseppe Fornarini, Sara Elena Rebuzzi, Pasquale Rescigno, Alfredo Addeo, Giuseppe L. Banna, Melissa Bersanelli

Risultato della ricerca: Contributo in rivista › Articolo in rivista

Abstract

The neutrophil-to-lymphocyte ratio (NLR) and systemic immune-inflammatory index (SII) have been re-ported as prognosticators in non-small cell lung cancer (NSCLC), renal cell carcinoma (RCC), and mela-noma. This analysis of the INVIDIa-2 study on influenza vaccination in patients with cancer treated with immune checkpoint inhibitors (ICIs) assessed NLR and SII on overall survival (OS) by literature-reported (LR), receiver operating characteristic curve (ROC)-derived (ROC) cutoffs or as continuous variable (CV). NLR and SII with ROC cutoffs of <3.4 (p < 0.001) and <831 (p < 0.001) were independent factors for OS in multivariate analysis. SII with LR, ROC, or CV significantly predicted OS in NSCLC (p = 0.002, p = 0.003, p = 0.003), RCC (p = 0.034, p = 0.014, p = 0.014), and melanoma (p = 0.038, p = 0.022, p = 0.019). NLR with LR and ROC cutoffs predicted OS in first line (p < 0.001 for both) and second line or beyond (p = 0.006 for both); likewise SII (p < 0.001; p = 0.002 and p < 0.001). NLR and SII are prognosti-cators in NSCLC, RCC, and melanoma treated with ICIs.

Lingua originale	English
pagine (da-a)	N/A-N/A
Rivista	iScience
Volume	26
DOI	https://doi.org/10.1016/j.isci.2023.107970
Stato di pubblicazione	Pubblicato - 2023

Keywords

Immune response
Immunity
Immunology

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10.1016/j.isci.2023.107970

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Anpalakhan, S., Signori, A., Cortellini, A., Verzoni, E., Giusti, R., Aprile, G., Ermacora, P., Catino, A., Pipitone, S., Di Napoli, M., Scotti, V., Mazzoni, F., Guglielmini, P. F., Veccia, A., Maruzzo, M., Schinzari, G., Casadei, C., Grossi, F., Rizzo, M., ... Bersanelli, M. (2023). Using peripheral immune-inflammatory blood markers in tumors treated with immune checkpoint inhibitors: An INVIDIa-2 study sub-analysis. iScience, 26, N/A-N/A. https://doi.org/10.1016/j.isci.2023.107970

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title = "Using peripheral immune-inflammatory blood markers in tumors treated with immune checkpoint inhibitors: An INVIDIa-2 study sub-analysis",

abstract = "The neutrophil-to-lymphocyte ratio (NLR) and systemic immune-inflammatory index (SII) have been re-ported as prognosticators in non-small cell lung cancer (NSCLC), renal cell carcinoma (RCC), and mela-noma. This analysis of the INVIDIa-2 study on influenza vaccination in patients with cancer treated with immune checkpoint inhibitors (ICIs) assessed NLR and SII on overall survival (OS) by literature-reported (LR), receiver operating characteristic curve (ROC)-derived (ROC) cutoffs or as continuous variable (CV). NLR and SII with ROC cutoffs of <3.4 (p < 0.001) and <831 (p < 0.001) were independent factors for OS in multivariate analysis. SII with LR, ROC, or CV significantly predicted OS in NSCLC (p = 0.002, p = 0.003, p = 0.003), RCC (p = 0.034, p = 0.014, p = 0.014), and melanoma (p = 0.038, p = 0.022, p = 0.019). NLR with LR and ROC cutoffs predicted OS in first line (p < 0.001 for both) and second line or beyond (p = 0.006 for both); likewise SII (p < 0.001; p = 0.002 and p < 0.001). NLR and SII are prognosti-cators in NSCLC, RCC, and melanoma treated with ICIs.",

keywords = "Immune response, Immunity, Immunology, Immune response, Immunity, Immunology",

author = "Shobana Anpalakhan and Alessio Signori and Alessio Cortellini and Elena Verzoni and Raffaele Giusti and Giuseppe Aprile and Paola Ermacora and Annamaria Catino and Stefania Pipitone and {Di Napoli}, Marilena and Vieri Scotti and Francesca Mazzoni and Guglielmini, {Pamela F.} and Antonello Veccia and Marco Maruzzo and Giovanni Schinzari and Chiara Casadei and Francesco Grossi and Mimma Rizzo and Vincenzo Montesarchio and Francesco Verderame and Manlio Mencoboni and Fable Zustovich and Lucia Fratino and Caterina Accettura and Saverio Cinieri and Tondini, {Carlo Alberto} and Andrea Camerini and Banzi, {Maria Chiara} and Mariella Sorar{\`u} and Zucali, {Paolo Andrea} and Francesca Vignani and Serena Ricciardi and Antonio Russo and Agnese Cosenza and {Di Maio}, Massimo and {De Giorgi}, Ugo and Sandro Pignata and Diana Giannarelli and Carmine Pinto and Sebastiano Buti and Giuseppe Fornarini and Rebuzzi, {Sara Elena} and Pasquale Rescigno and Alfredo Addeo and Banna, {Giuseppe L.} and Melissa Bersanelli",

year = "2023",

doi = "10.1016/j.isci.2023.107970",

language = "English",

volume = "26",

pages = "N/A--N/A",

journal = "iScience",

issn = "2589-0042",

publisher = "Elsevier Inc.",

}

Anpalakhan, S, Signori, A, Cortellini, A, Verzoni, E, Giusti, R, Aprile, G, Ermacora, P, Catino, A, Pipitone, S, Di Napoli, M, Scotti, V, Mazzoni, F, Guglielmini, PF, Veccia, A, Maruzzo, M, Schinzari, G, Casadei, C, Grossi, F, Rizzo, M, Montesarchio, V, Verderame, F, Mencoboni, M, Zustovich, F, Fratino, L, Accettura, C, Cinieri, S, Tondini, CA, Camerini, A, Banzi, MC, Sorarù, M, Zucali, PA, Vignani, F, Ricciardi, S, Russo, A, Cosenza, A, Di Maio, M, De Giorgi, U, Pignata, S, Giannarelli, D, Pinto, C, Buti, S, Fornarini, G, Rebuzzi, SE, Rescigno, P, Addeo, A, Banna, GL & Bersanelli, M 2023, 'Using peripheral immune-inflammatory blood markers in tumors treated with immune checkpoint inhibitors: An INVIDIa-2 study sub-analysis', iScience, vol. 26, pagg. N/A-N/A. https://doi.org/10.1016/j.isci.2023.107970

TY - JOUR

T1 - Using peripheral immune-inflammatory blood markers in tumors treated with immune checkpoint inhibitors: An INVIDIa-2 study sub-analysis

AU - Anpalakhan, Shobana

AU - Signori, Alessio

AU - Cortellini, Alessio

AU - Verzoni, Elena

AU - Giusti, Raffaele

AU - Aprile, Giuseppe

AU - Ermacora, Paola

AU - Catino, Annamaria

AU - Pipitone, Stefania

AU - Di Napoli, Marilena

AU - Scotti, Vieri

AU - Mazzoni, Francesca

AU - Guglielmini, Pamela F.

AU - Veccia, Antonello

AU - Maruzzo, Marco

AU - Schinzari, Giovanni

AU - Casadei, Chiara

AU - Grossi, Francesco

AU - Rizzo, Mimma

AU - Montesarchio, Vincenzo

AU - Verderame, Francesco

AU - Mencoboni, Manlio

AU - Zustovich, Fable

AU - Fratino, Lucia

AU - Accettura, Caterina

AU - Cinieri, Saverio

AU - Tondini, Carlo Alberto

AU - Camerini, Andrea

AU - Banzi, Maria Chiara

AU - Sorarù, Mariella

AU - Zucali, Paolo Andrea

AU - Vignani, Francesca

AU - Ricciardi, Serena

AU - Russo, Antonio

AU - Cosenza, Agnese

AU - Di Maio, Massimo

AU - De Giorgi, Ugo

AU - Pignata, Sandro

AU - Giannarelli, Diana

AU - Pinto, Carmine

AU - Buti, Sebastiano

AU - Fornarini, Giuseppe

AU - Rebuzzi, Sara Elena

AU - Rescigno, Pasquale

AU - Addeo, Alfredo

AU - Banna, Giuseppe L.

AU - Bersanelli, Melissa

PY - 2023

Y1 - 2023

N2 - The neutrophil-to-lymphocyte ratio (NLR) and systemic immune-inflammatory index (SII) have been re-ported as prognosticators in non-small cell lung cancer (NSCLC), renal cell carcinoma (RCC), and mela-noma. This analysis of the INVIDIa-2 study on influenza vaccination in patients with cancer treated with immune checkpoint inhibitors (ICIs) assessed NLR and SII on overall survival (OS) by literature-reported (LR), receiver operating characteristic curve (ROC)-derived (ROC) cutoffs or as continuous variable (CV). NLR and SII with ROC cutoffs of <3.4 (p < 0.001) and <831 (p < 0.001) were independent factors for OS in multivariate analysis. SII with LR, ROC, or CV significantly predicted OS in NSCLC (p = 0.002, p = 0.003, p = 0.003), RCC (p = 0.034, p = 0.014, p = 0.014), and melanoma (p = 0.038, p = 0.022, p = 0.019). NLR with LR and ROC cutoffs predicted OS in first line (p < 0.001 for both) and second line or beyond (p = 0.006 for both); likewise SII (p < 0.001; p = 0.002 and p < 0.001). NLR and SII are prognosti-cators in NSCLC, RCC, and melanoma treated with ICIs.

AB - The neutrophil-to-lymphocyte ratio (NLR) and systemic immune-inflammatory index (SII) have been re-ported as prognosticators in non-small cell lung cancer (NSCLC), renal cell carcinoma (RCC), and mela-noma. This analysis of the INVIDIa-2 study on influenza vaccination in patients with cancer treated with immune checkpoint inhibitors (ICIs) assessed NLR and SII on overall survival (OS) by literature-reported (LR), receiver operating characteristic curve (ROC)-derived (ROC) cutoffs or as continuous variable (CV). NLR and SII with ROC cutoffs of <3.4 (p < 0.001) and <831 (p < 0.001) were independent factors for OS in multivariate analysis. SII with LR, ROC, or CV significantly predicted OS in NSCLC (p = 0.002, p = 0.003, p = 0.003), RCC (p = 0.034, p = 0.014, p = 0.014), and melanoma (p = 0.038, p = 0.022, p = 0.019). NLR with LR and ROC cutoffs predicted OS in first line (p < 0.001 for both) and second line or beyond (p = 0.006 for both); likewise SII (p < 0.001; p = 0.002 and p < 0.001). NLR and SII are prognosti-cators in NSCLC, RCC, and melanoma treated with ICIs.

KW - Immune response

KW - Immunity

KW - Immunology

KW - Immune response

KW - Immunity

KW - Immunology

UR - http://hdl.handle.net/10807/304643

U2 - 10.1016/j.isci.2023.107970

DO - 10.1016/j.isci.2023.107970

M3 - Article

SN - 2589-0042

VL - 26

SP - N/A-N/A

JO - iScience

JF - iScience

ER -

Using peripheral immune-inflammatory blood markers in tumors treated with immune checkpoint inhibitors: An INVIDIa-2 study sub-analysis

Abstract

Keywords

OSS delle Nazioni Unite

Accesso al documento

Altri file e collegamenti

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