TY - JOUR
T1 - Usefulness of brain positron emission tomography with different tracers in the evaluation of patients with idiopathic normal pressure hydrocephalous
AU - Mattoli, Maria Vittoria
AU - Treglia, Giorgio
AU - Calcagni, Maria Lucia
AU - Mangiola, Annunziato
AU - Anile, Carmelo
AU - Trevisi, Gianluca
AU - Trevisi, Giuseppe
PY - 2020
Y1 - 2020
N2 - Idiopathic normal pressure hydrocephalus (iNPH) is the only form of dementia that can be cured by surgery. Its diagnosis relies on clinical and radiological criteria. Identifying patients who can benefit from surgery is challenging, as other neurological diseases can be concomitant or mimic iNPH. We performed a systematic review on the role of positron emission tomography (PET) in iNPH. We retrieved 35 papers evaluating four main functional aspects with different PET radiotracers: (1) PET with amyloid tracers, revealing Alzheimer’s disease (AD) pathology in 20–57% of suspected iNPH patients, could be useful in predictions of surgical outcome. (2) PET with radiolabeled water as perfusion tracer showed a global decreased cerebral blood flow (CBF) and regional reduction of CBF in basal ganglia in iNPH; preoperative perfusion parameters could predict surgical outcome. (3) PET with 2-Deoxy-2-[18F]fluoroglucose ([18F]FDG ) showed a global reduction of glucose metabolism without a specific cortical pattern and a hypometabolism in basal ganglia; [18F]FDG PET may identify a coexisting neurodegenerative disease, helping in patient selection for surgery; postsurgery increase in glucose metabolism was associated with clinical improvement. (4) Dopaminergic PET imaging showed a postsynaptic D2 receptor reduction and striatal upregulation of D2 receptor after treatment, associated with clinical improvement. Overall, PET imaging could be a useful tool in iNPH diagnoses and treatment response.
AB - Idiopathic normal pressure hydrocephalus (iNPH) is the only form of dementia that can be cured by surgery. Its diagnosis relies on clinical and radiological criteria. Identifying patients who can benefit from surgery is challenging, as other neurological diseases can be concomitant or mimic iNPH. We performed a systematic review on the role of positron emission tomography (PET) in iNPH. We retrieved 35 papers evaluating four main functional aspects with different PET radiotracers: (1) PET with amyloid tracers, revealing Alzheimer’s disease (AD) pathology in 20–57% of suspected iNPH patients, could be useful in predictions of surgical outcome. (2) PET with radiolabeled water as perfusion tracer showed a global decreased cerebral blood flow (CBF) and regional reduction of CBF in basal ganglia in iNPH; preoperative perfusion parameters could predict surgical outcome. (3) PET with 2-Deoxy-2-[18F]fluoroglucose ([18F]FDG ) showed a global reduction of glucose metabolism without a specific cortical pattern and a hypometabolism in basal ganglia; [18F]FDG PET may identify a coexisting neurodegenerative disease, helping in patient selection for surgery; postsurgery increase in glucose metabolism was associated with clinical improvement. (4) Dopaminergic PET imaging showed a postsynaptic D2 receptor reduction and striatal upregulation of D2 receptor after treatment, associated with clinical improvement. Overall, PET imaging could be a useful tool in iNPH diagnoses and treatment response.
KW - 18
KW - Alzheimer Disease
KW - Amyloid
KW - Amyloidogenic Proteins
KW - Biomarker
KW - Brain
KW - Cerebrovascular Circulation
KW - Dopaminergic
KW - F]FDG
KW - Fluorodeoxyglucose F18
KW - Humans
KW - Hydrocephalous
KW - Hydrocephalus, Normal Pressure
KW - Neurodegenerative Diseases
KW - PET
KW - Perfusion
KW - Positron emission tomography
KW - Positron-Emission Tomography
KW - Ventriculo-peritoneal shunt
KW - Ventriculoperitoneal Shunt
KW - [
KW - tau Proteins
KW - 18
KW - Alzheimer Disease
KW - Amyloid
KW - Amyloidogenic Proteins
KW - Biomarker
KW - Brain
KW - Cerebrovascular Circulation
KW - Dopaminergic
KW - F]FDG
KW - Fluorodeoxyglucose F18
KW - Humans
KW - Hydrocephalous
KW - Hydrocephalus, Normal Pressure
KW - Neurodegenerative Diseases
KW - PET
KW - Perfusion
KW - Positron emission tomography
KW - Positron-Emission Tomography
KW - Ventriculo-peritoneal shunt
KW - Ventriculoperitoneal Shunt
KW - [
KW - tau Proteins
UR - http://hdl.handle.net/10807/177068
U2 - 10.3390/ijms21186523
DO - 10.3390/ijms21186523
M3 - Article
SN - 1661-6596
VL - 21
SP - 1
EP - 22
JO - International Journal of Molecular Sciences
JF - International Journal of Molecular Sciences
ER -