Use of fibrin sealant for reproductive surgery: A randomized study in the rabbit model

Riccardo Marana, L Muzii, G. F Catalano, P Caruana, Salvatore Mancuso

Risultato della ricerca: Contributo in rivistaArticolo in rivista

10 Citazioni (Scopus)


The present study was undertaken to compare adhesion formation and reproductive outcome after reproductive surgery with or without the application of fibrin sealant. At laparotomy, the ovaries and uterine horns of 20 rabbits were longitudinally incised on the antimesenteric side using a monopolar microneedle. At random, one ovary and the ipsilateral uterine horn were covered with fibrin sealant, while those on the contralateral side were left uncovered without application of sutures. The rabbits were then mated, and 2 weeks later a second-look laparotomy was performed by a blinded observer. No statistically significant differences were found in postoperative adhesions, number of corpora lutea in each ovary, number of embryos in the ipsilateral uterine horn, and nidation index for each side. Fibrin sealant for conservative surgery does not appear to significantly affect either postoperative adhesion formation or reproductive outcome.
Lingua originaleEnglish
pagine (da-a)199-202
Numero di pagine4
RivistaGynecologic and Obstetric Investigation
Stato di pubblicazionePubblicato - 1996


  • Animals
  • Female
  • Fibrin Tissue Adhesive
  • Male
  • Ovarian Diseases
  • Ovary
  • Prospective Studies
  • Rabbits
  • Random Allocation
  • Tissue Adhesives
  • Uterine Diseases
  • Uterus
  • animal model
  • article
  • controlled study
  • experimental surgery
  • female
  • fibrin glue
  • gynecologic surgery
  • laparotomy
  • nidation
  • nonhuman
  • ovary
  • postoperative complication
  • priority journal
  • rabbit
  • sealant, animal experiment
  • second look surgery
  • suture
  • uterus, Adhesions


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