Urinary excretion of glycosaminoglycans in patients with isolated nocturnal enuresis or combined with diurnal incontinence

P. Ferrara, Donato Rigante, S. Lambert-Gardini, E. Salvaggio, R. Ricci, M. L. Chiozza, D. Antuzzi

Risultato della ricerca: Contributo in rivistaArticolo in rivista

Abstract

Objective To determine variations in the amount of glycosaminoglycans (GAGs) excreted by patients with nocturnal enuresis and/or diurnal incontinence. Patients, subjects and methods The study included 27 patients (aged 5-15 years) with nocturnal enuresis and/or diurnal incontinence, and 27 healthy age-matched children. Their urinary GAG excretion was assessed over 24 h using the sodium tetraboratecarbazole method. Results Patients with nocturnal enuresis and/or diurnal incontinence had higher mean values of urinary GAG excretion than age-matched controls. There were significant differences in GAG excretion between those with nocturnal enuresis and diurnal incontinence and those with nocturnal enuresis alone. Conclusions GAG excretion in patients with nocturnal enuresis and/or diurnal incontinence was significantly higher than in normal children, suggesting that measuring urinary GAGs may be useful in evaluating physiopathological conditions of the bladder wall, and hence in monitoring potential damage in the bladder mucosa.
Lingua originaleEnglish
pagine (da-a)824-825
Numero di pagine2
RivistaBJU International
Volume86
DOI
Stato di pubblicazionePubblicato - 2000

Keywords

  • Bladder wall
  • Diurnal incontinence
  • Glycosaminoglycans
  • Nocturnal enuresis

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