Urinary Albumin Detection: Comparison of Two Different Methods

Rossana Molinario, Krizia Pocino, Angela Giannace, Cecilia Zuppi, Mirca Antenucci

Risultato della ricerca: Contributo in rivistaArticolo in rivista

3 Citazioni (Scopus)

Abstract

BackgroundMonitoring urinary albumin is a useful method in clinical practice for the management of diabetic nephropathy, chronic kidney disease, and hypertension. Currently there are neither standardized methods nor reference material for the determination of urinary albumin; for this reason it is useful to compare different assays used in clinical laboratory. ObjectivesThe aim of this study is to verify analytical performance of an immunoturbidimetric assay on Roche Cobas 8000 platform and to compare urinary albumin results with those obtained by immunonephelometry on Siemens Dade Behring BN II Nephelometer. ResultsThe method comparison showed a good linear relationship, confirmed by Passing-Bablok and Bland-Altman plots. The turbidimetric assay meets the requirements of accuracy and precision for the practice of medical diagnostics and clinical use. ConclusionsThe present study can contribute to the methods standardization and harmonization of urinary albumin assay.
Lingua originaleEnglish
pagine (da-a)888-891
Numero di pagine4
RivistaJournal of Clinical Laboratory Analysis
Volume30
DOI
Stato di pubblicazionePubblicato - 2016

Keywords

  • method evaluation
  • urinary albumin

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