Upfront Fluorouracil, Leucovorin, Oxaliplatin, and Irinotecan Plus Bevacizumab with or Without Atezolizumab for Patients with Metastatic Colorectal Cancer: Updated and Overall Survival Results of the ATEZOTRIBE Study

C. Antoniotti, D. Rossini, Filomena Pietrantonio, Lisa Salvatore, S. Lonardi, S. Tamberi, F. Marmorino, R. Moretto, M. Prisciandaro, E. Tamburini, Giampaolo Tortora, A. Passardi, F. Bergamo, A. Raimondi, G. Ritorto, B. Borelli, V. Conca, C. Ugolini, G. Aprile, L. AntonuzzoF. Gelsomino, E. Martinelli, N. Pella, G. Masi, L. Boni, J. Galon, C. Cremolini

Risultato della ricerca: Contributo in rivistaArticolo in rivista

Abstract

Clinical trials frequently include multiple end points that mature at different times. The initial report, typically based on the primary end point, may be published when key planned co-primary or secondary analyses are not yet available. Clinical Trial Updates provide an opportunity to disseminate additional results from studies, published in JCO or elsewhere, for which the primary end point has already been reported.We report 4-year results of the phase II randomized AtezoTRIBE study. Eligible patients with metastatic colorectal cancer (mCRC) received first-line fluorouracil, leucovorin, oxaliplatin, and irinotecan (FOLFOXIRI)/bevacizumab (control group, n = 73) or FOLFOXIRI/bevacizumab plus atezolizumab (experimental group, n = 145). We present overall survival (OS) and updated outcomes according to tumor immune-related biomarkers, both in the intention-To-Treat (ITT) population and the cohort of patients with proficient mismatch repair (pMMR) tumors. Median follow-up was 45.2 months (IQR, 42.6-49.2). In t
Lingua originaleEnglish
pagine (da-a)2637-2644
Numero di pagine8
RivistaJournal of Clinical Oncology
Volume42
DOI
Stato di pubblicazionePubblicato - 2024

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