Update on emergence of HIV-1 resistance to antiretroviral drug classes in an Italian national database: 2007-2009

Simona Di Giambenedetto; M Prosperi; Iuri Fanti; B Bruzzone; Sabrina Paolucci; G Penco; G Meini; A Di Biagio; E Paolini; V Micheli; P Meraviglia; P Castelli; Paola Corsi; A Gonnelli; Massimiliano Fabbiani; M Zazzi; Andrea De Luca

doi:10.1111/j.1469-0691.2011.03563.x

Update on emergence of HIV-1 resistance to antiretroviral drug classes in an Italian national database: 2007-2009

Simona Di Giambenedetto, M Prosperi, Iuri Fanti, B Bruzzone, Sabrina Paolucci, G Penco, G Meini, A Di Biagio, E Paolini, V Micheli, P Meraviglia, P Castelli, Paola Corsi, A Gonnelli, Massimiliano Fabbiani, M Zazzi, Andrea De Luca

Risultato della ricerca: Contributo in rivista › Articolo in rivista

6 Citazioni (Scopus)

Abstract

We analysed trends of human immunodeficiency virus type 1 (HIV-1) drug resistance during 2007-2009 in the Italian national HIV drug resistance database 'ARCA'. Prevalence of resistance in each year was examined on the basis of the presence of major International AIDS Society-2009 mutations. Predictors of resistance were analysed by multivariable logistic regression. Nine hundred and sixty-six patients were selected. Resistance to nucleoside reverse transcriptase inhibitors and protease inhibitors showed a significant decline with respect to previous surveys. Resistance to any class of drug and three drug classes remained stable. Independent predictors of three-class resistance were the number of treatment regimens experienced, prior suboptimal nucleoside reverse transcriptase inhibitor therapy and the current use of ritonavir-boosted protease inhibitors.

Lingua originale	English
pagine (da-a)	1352-1355
Numero di pagine	4
Rivista	Clinical Microbiology and Infection
Volume	17
DOI	https://doi.org/10.1111/j.1469-0691.2011.03563.x
Stato di pubblicazione	Pubblicato - 2011

Keywords

Adult
Anti-HIV Agents
Antiretroviral Therapy, Highly Active
Databases, Factual
Drug Resistance, Viral
Female
HIV Infections
HIV-1
Humans
Italy
Logistic Models
Male
Middle Aged
Prevalence
Treatment Failure

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Di Giambenedetto, S., Prosperi, M., Fanti, I., Bruzzone, B., Paolucci, S., Penco, G., Meini, G., Di Biagio, A., Paolini, E., Micheli, V., Meraviglia, P., Castelli, P., Corsi, P., Gonnelli, A., Fabbiani, M., Zazzi, M., & De Luca, A. (2011). Update on emergence of HIV-1 resistance to antiretroviral drug classes in an Italian national database: 2007-2009. Clinical Microbiology and Infection, 17, 1352-1355. https://doi.org/10.1111/j.1469-0691.2011.03563.x

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title = "Update on emergence of HIV-1 resistance to antiretroviral drug classes in an Italian national database: 2007-2009",

abstract = "We analysed trends of human immunodeficiency virus type 1 (HIV-1) drug resistance during 2007-2009 in the Italian national HIV drug resistance database 'ARCA'. Prevalence of resistance in each year was examined on the basis of the presence of major International AIDS Society-2009 mutations. Predictors of resistance were analysed by multivariable logistic regression. Nine hundred and sixty-six patients were selected. Resistance to nucleoside reverse transcriptase inhibitors and protease inhibitors showed a significant decline with respect to previous surveys. Resistance to any class of drug and three drug classes remained stable. Independent predictors of three-class resistance were the number of treatment regimens experienced, prior suboptimal nucleoside reverse transcriptase inhibitor therapy and the current use of ritonavir-boosted protease inhibitors.",

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author = "{Di Giambenedetto}, Simona and M Prosperi and Iuri Fanti and B Bruzzone and Sabrina Paolucci and G Penco and G Meini and {Di Biagio}, A and E Paolini and V Micheli and P Meraviglia and P Castelli and Paola Corsi and A Gonnelli and Massimiliano Fabbiani and M Zazzi and {De Luca}, Andrea",

year = "2011",

doi = "10.1111/j.1469-0691.2011.03563.x",

language = "English",

volume = "17",

pages = "1352--1355",

journal = "Clinical Microbiology and Infection",

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Di Giambenedetto, S, Prosperi, M, Fanti, I, Bruzzone, B, Paolucci, S, Penco, G, Meini, G, Di Biagio, A, Paolini, E, Micheli, V, Meraviglia, P, Castelli, P, Corsi, P, Gonnelli, A, Fabbiani, M, Zazzi, M & De Luca, A 2011, 'Update on emergence of HIV-1 resistance to antiretroviral drug classes in an Italian national database: 2007-2009', Clinical Microbiology and Infection, vol. 17, pagg. 1352-1355. https://doi.org/10.1111/j.1469-0691.2011.03563.x

TY - JOUR

T1 - Update on emergence of HIV-1 resistance to antiretroviral drug classes in an Italian national database: 2007-2009

AU - Di Giambenedetto, Simona

AU - Prosperi, M

AU - Fanti, Iuri

AU - Bruzzone, B

AU - Paolucci, Sabrina

AU - Penco, G

AU - Meini, G

AU - Di Biagio, A

AU - Paolini, E

AU - Micheli, V

AU - Meraviglia, P

AU - Castelli, P

AU - Corsi, Paola

AU - Gonnelli, A

AU - Fabbiani, Massimiliano

AU - Zazzi, M

AU - De Luca, Andrea

PY - 2011

Y1 - 2011

N2 - We analysed trends of human immunodeficiency virus type 1 (HIV-1) drug resistance during 2007-2009 in the Italian national HIV drug resistance database 'ARCA'. Prevalence of resistance in each year was examined on the basis of the presence of major International AIDS Society-2009 mutations. Predictors of resistance were analysed by multivariable logistic regression. Nine hundred and sixty-six patients were selected. Resistance to nucleoside reverse transcriptase inhibitors and protease inhibitors showed a significant decline with respect to previous surveys. Resistance to any class of drug and three drug classes remained stable. Independent predictors of three-class resistance were the number of treatment regimens experienced, prior suboptimal nucleoside reverse transcriptase inhibitor therapy and the current use of ritonavir-boosted protease inhibitors.

AB - We analysed trends of human immunodeficiency virus type 1 (HIV-1) drug resistance during 2007-2009 in the Italian national HIV drug resistance database 'ARCA'. Prevalence of resistance in each year was examined on the basis of the presence of major International AIDS Society-2009 mutations. Predictors of resistance were analysed by multivariable logistic regression. Nine hundred and sixty-six patients were selected. Resistance to nucleoside reverse transcriptase inhibitors and protease inhibitors showed a significant decline with respect to previous surveys. Resistance to any class of drug and three drug classes remained stable. Independent predictors of three-class resistance were the number of treatment regimens experienced, prior suboptimal nucleoside reverse transcriptase inhibitor therapy and the current use of ritonavir-boosted protease inhibitors.

KW - Adult

KW - Anti-HIV Agents

KW - Antiretroviral Therapy, Highly Active

KW - Databases, Factual

KW - Drug Resistance, Viral

KW - Female

KW - HIV Infections

KW - HIV-1

KW - Humans

KW - Italy

KW - Logistic Models

KW - Male

KW - Middle Aged

KW - Prevalence

KW - Treatment Failure

KW - Adult

KW - Anti-HIV Agents

KW - Antiretroviral Therapy, Highly Active

KW - Databases, Factual

KW - Drug Resistance, Viral

KW - Female

KW - HIV Infections

KW - HIV-1

KW - Humans

KW - Italy

KW - Logistic Models

KW - Male

KW - Middle Aged

KW - Prevalence

KW - Treatment Failure

UR - http://hdl.handle.net/10807/6339

U2 - 10.1111/j.1469-0691.2011.03563.x

DO - 10.1111/j.1469-0691.2011.03563.x

M3 - Article

SN - 1469-0691

VL - 17

SP - 1352

EP - 1355

JO - Clinical Microbiology and Infection

JF - Clinical Microbiology and Infection

ER -

Update on emergence of HIV-1 resistance to antiretroviral drug classes in an Italian national database: 2007-2009

Abstract

Keywords

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