Update on emergence of HIV-1 resistance to antiretroviral drug classes in an Italian national database: 2007-2009

Simona Di Giambenedetto, Iuri Fanti, Massimiliano Fabbiani, Andrea De Luca, M Prosperi, B Bruzzone, Sabrina Paolucci, G Penco, G Meini, A Di Biagio, E Paolini, V Micheli, P Meraviglia, P Castelli, Paola Corsi, A Gonnelli, M Zazzi

Risultato della ricerca: Contributo in rivistaArticolo in rivista

6 Citazioni (Scopus)

Abstract

We analysed trends of human immunodeficiency virus type 1 (HIV-1) drug resistance during 2007-2009 in the Italian national HIV drug resistance database 'ARCA'. Prevalence of resistance in each year was examined on the basis of the presence of major International AIDS Society-2009 mutations. Predictors of resistance were analysed by multivariable logistic regression. Nine hundred and sixty-six patients were selected. Resistance to nucleoside reverse transcriptase inhibitors and protease inhibitors showed a significant decline with respect to previous surveys. Resistance to any class of drug and three drug classes remained stable. Independent predictors of three-class resistance were the number of treatment regimens experienced, prior suboptimal nucleoside reverse transcriptase inhibitor therapy and the current use of ritonavir-boosted protease inhibitors.
Lingua originaleEnglish
pagine (da-a)1352-1355
Numero di pagine4
RivistaClinical Microbiology and Infection
Volume17
DOI
Stato di pubblicazionePubblicato - 2011

Keywords

  • Adult
  • Anti-HIV Agents
  • Antiretroviral Therapy, Highly Active
  • Databases, Factual
  • Drug Resistance, Viral
  • Female
  • HIV Infections
  • HIV-1
  • Humans
  • Italy
  • Logistic Models
  • Male
  • Middle Aged
  • Prevalence
  • Treatment Failure

Fingerprint Entra nei temi di ricerca di 'Update on emergence of HIV-1 resistance to antiretroviral drug classes in an Italian national database: 2007-2009'. Insieme formano una fingerprint unica.

Cita questo