Unusual focal keratin expression in plexiform angiomyxoid myofibroblastic tumor: A case report and review of the literature

Maurizio Martini, Sergio Alfieri, Riccardo Ricci, Giuseppe Quero, Teresa Musarra, Michelangelo Fici, Alfredo Carrato, Angelo Paolo Dei Tos

Risultato della ricerca: Contributo in rivistaArticolo in rivistapeer review

11 Citazioni (Scopus)

Abstract

Background: Plexiform angiomyxoid myofibroblastic tumor (PAMT), also known as plexiform fibromyxoma, is a rare distinctive benign intramural tumor, typical of gastric antrum, commonly causing mucosal ulceration with upper gastrointestinal bleeding and anemia, effectively treated by complete surgical resection usually accomplished by distal gastrectomy. Methods and Results: We herein report a 47-year-old man presenting with a syncopal episode, regurgitation and epigastric discomfort, bearing a gastric antral myxoid plexiform tumor positive for α-smooth muscle actin, vimentin and, partially, for caldesmon, desmin, and CD10; CD117, DOG1, CD34, S100, CAM5.2, CK20, CK7, EMA, p53, CDX2, chromogranin A, synaptophysin, anaplastic lymphoma kinase, Melan-A, and HMB-45 were all negative. All these features are typical of PAMT. Of note, focal positivity for AE1/AE3 and pan-CK KL1 was also present. Conclusions: The finding of a focal keratin expression in PAMT contributes to enlarge the immunophenotypic spectrum of this tumor type and is relevant for avoiding presurgical misdiagnoses which could ultimately lead to inappropriate overtreatment of patients with PAMT.
Lingua originaleEnglish
pagine (da-a)e4207-N/A/A
Numero di pagine6
RivistaMEDICINE
Volume95
DOI
Stato di pubblicazionePubblicato - 2016

Keywords

  • Medicine (all)
  • differential diagnosis
  • histopathology
  • immunohistochemistry
  • plexiform angiomyxoid myofibroblastic tumor
  • plexiform fibromyxoma

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