Unmasking the impact of Rictor in cancer: Novel insights of mTORC2 complex

Giampaolo Tortora, Emilio Bria, Anastasios Gkountakos, Sara Pilotto, Andrea Mafficini, Caterina Vicentini, Michele Simbolo, Michele Milella, Aldo Scarpa, Vincenzo Corbo

Risultato della ricerca: Contributo in rivistaArticolo in rivista

21 Citazioni (Scopus)

Abstract

Genomic alterations affecting components of the mechanistic target of rapamycin (mTOR) pathway are found rather frequently in cancers, suggesting that aberrant pathway activity is implicated in oncogenesis of different tumor types. mTOR functions as the core catalytic kinase of two distinct complexes, mTOR complex 1 (mTORC1) and 2 (mTORC2), which control numerous vital cellular processes. There is growing evidence indicating that Rictor, an essential subunit of the mTORC2 complex, is inappropriately overexpressed across numerous cancer types and this is associated with poor survival. To date, the candidate mechanisms responsible for aberrant Rictor expression described in cancer are two: (i) gene amplification and (ii) epigenetic regulation, mainly by microRNAs. Moreover, different mTOR-independent Rictor-containing complexes with oncogenic role have been documented, revealing alternative routes of Rictor-driven tumorigenesis, but simultaneously, paving the way for identifying novel biomarkers and therapeutic targets. Here, we review the main preclinical and clinical data regarding the role of Rictor in carcinogenesis and metastatic behavior as well as the potentiality of its alteration as a target.
Lingua originaleEnglish
pagine (da-a)971-980
Numero di pagine10
RivistaCarcinogenesis
Volume39
DOI
Stato di pubblicazionePubblicato - 2018

Keywords

  • Cancer Research

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