Understanding the effect of acromegaly on the human skeleton.

Sabrina Chiloiro, Serena Piacentini, Antonella Giampietro, Linda Tartaglione, Antonio Bianchi, Laura De Marinis Grasso

Risultato della ricerca: Contributo in rivistaArticolo in rivista

Abstract

Acromegaly, caused in most cases by Growth Hormone (GH)-secreting pituitary adenomas, is characterized by increased skeletal growth and enlargement of the soft tissue, because GH and its effector Insulin-like Growth factor-1 are important regulators of bone homeostasis and have a central role in the longitudinal bone growth and maintenance of bone mass. Areas covered: Despite the anabolic effect of these hormones is well known, as a result of the stimulation of bone turnover and especially of bone formation, many acromegalic patients are suffering from a form of secondary osteoporosis with increased risk of fractures. Expert commentary: In this review, we summarize the pathophysiology, diagnosis, clinical picture, disease course and management of skeletal complications of acromegaly, focusing in particular on secondary osteoporosis and fracture risk in acromegaly.
Lingua originaleEnglish
pagine (da-a)263-270
Numero di pagine8
RivistaEXPERT REVIEW OF ENDOCRINOLOGY & METABOLISM
DOI
Stato di pubblicazionePubblicato - 2016

Keywords

  • acromegaly

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