TY - JOUR
T1 - Uncommon BRAF mutations in the follicular variant of thyroid papillary carcinoma: New insights
AU - Rossi, Esther
AU - Martini, Maurizio
AU - Bizzarro, Tommaso
AU - Capodimonti, Sara
AU - Cenci, Tonia
AU - Lombardi, Celestino Pio
AU - Pontecorvi, Alfredo
AU - Fadda, Guido
AU - Larocca, Luigi Maria
PY - 2015
Y1 - 2015
N2 - Mutational analysis is reshaping the practice of fine-needle aspiration cytology for the diagnosis of thyroid nodules. The v-Raf murine sarcoma viral oncogene homolog B1 (BRAF) valine (V) to glutamic acid (E) substitution at codon 600 (BRAF(V600E)) is the most effective diagnostic/prognostic marker and is used mainly for papillary thyroid carcinomas (PTCs). Although BRAF(V600E) represents 95% of all BRAF mutations, uncommon BRAF mutations have been identified in thyroid carcinomas. For the current study, the authors evaluated morphologic (plump pink cells and sickle-shaped nuclei) anti-BRAF(V600E) antibody (VE1) immunocytochemical and molecular findings of BRAF mutations in PTCs and in the follicular variant of PTC (FVPC).
AB - Mutational analysis is reshaping the practice of fine-needle aspiration cytology for the diagnosis of thyroid nodules. The v-Raf murine sarcoma viral oncogene homolog B1 (BRAF) valine (V) to glutamic acid (E) substitution at codon 600 (BRAF(V600E)) is the most effective diagnostic/prognostic marker and is used mainly for papillary thyroid carcinomas (PTCs). Although BRAF(V600E) represents 95% of all BRAF mutations, uncommon BRAF mutations have been identified in thyroid carcinomas. For the current study, the authors evaluated morphologic (plump pink cells and sickle-shaped nuclei) anti-BRAF(V600E) antibody (VE1) immunocytochemical and molecular findings of BRAF mutations in PTCs and in the follicular variant of PTC (FVPC).
KW - BRAF mutations
KW - follicular neoplasms
KW - follicular variant of papillary thyroid carcinoma
KW - liquid-based cytology
KW - papillary thyroid carcinoma
KW - BRAF mutations
KW - follicular neoplasms
KW - follicular variant of papillary thyroid carcinoma
KW - liquid-based cytology
KW - papillary thyroid carcinoma
UR - http://hdl.handle.net/10807/70156
U2 - 10.1002/cncy.21586
DO - 10.1002/cncy.21586
M3 - Article
SN - 1934-662X
VL - 123
SP - 593
EP - 602
JO - Cancer cytopathology
JF - Cancer cytopathology
ER -