TY - JOUR
T1 - Umbilical cord blood: Current uses for transfusion and regenerative medicine
AU - Orlando, Nicoletta
AU - Pellegrino, Claudio
AU - Valentini, Caterina Giovanna
AU - Bianchi, Maria
AU - Barbagallo, Ombretta
AU - Sparnacci, Sabrina
AU - Forni, Franca
AU - Fontana, Tecla Maria
AU - Teofili, Luciana
PY - 2020
Y1 - 2020
N2 - The past 20 years of experience with umbilical cord blood transplantation have demonstrated that cord blood is effective in the treatment of a spectrum of diseases, including hematological malignancies, bone marrow failure, hemoglobinopathies, and inborn errors of metabolism. However, only a few number of umbilical cord blood units collected have a cell content adequate for an allogenic hematopoietic stem cell transplantation. In the meanwhile, there is an increasing interest in exploiting cord blood derivatives in different fields. In this review, we will summarize the most recent updates on clinical applications of umbilical cord blood platelet derivatives for regenerative medicine, and we will revise the literature concerning the use of umbilical cord blood for autologous or allogeneic transfusion purposes. The methodological aspect and the biological characteristics of these products also will be discussed.
AB - The past 20 years of experience with umbilical cord blood transplantation have demonstrated that cord blood is effective in the treatment of a spectrum of diseases, including hematological malignancies, bone marrow failure, hemoglobinopathies, and inborn errors of metabolism. However, only a few number of umbilical cord blood units collected have a cell content adequate for an allogenic hematopoietic stem cell transplantation. In the meanwhile, there is an increasing interest in exploiting cord blood derivatives in different fields. In this review, we will summarize the most recent updates on clinical applications of umbilical cord blood platelet derivatives for regenerative medicine, and we will revise the literature concerning the use of umbilical cord blood for autologous or allogeneic transfusion purposes. The methodological aspect and the biological characteristics of these products also will be discussed.
KW - Allogenic cord RBC
KW - Umbilical cord blood transfusion
KW - Umbilical cord blood serum
KW - Umbilical cord blood platelet gel
KW - Allogenic cord RBC
KW - Umbilical cord blood transfusion
KW - Umbilical cord blood serum
KW - Umbilical cord blood platelet gel
UR - http://hdl.handle.net/10807/305456
U2 - 10.1016/j.transci.2020.102952
DO - 10.1016/j.transci.2020.102952
M3 - Article
SN - 1473-0502
VL - 59
SP - N/A-N/A
JO - Transfusion and Apheresis Science
JF - Transfusion and Apheresis Science
ER -