Type 1 immune response in progressive Multiple Sclerosis

Giovanni Frisullo; Domenico Plantone; Alessandro Marti; Raffaele Iorio; V Damato; Alessandro Bianco; Viviana Nociti; Agata Katia Patanella; Anna Paola Batocchi

doi:10.1016/j.jneuroim.2012.04.019

Type 1 immune response in progressive Multiple Sclerosis

Giovanni Frisullo
, Domenico Plantone
, Alessandro Marti
, Raffaele Iorio
, V Damato
, Alessandro Bianco
, Viviana Nociti
, Agata Katia Patanella
, Anna Paola Batocchi^*

^*Autore corrispondente per questo lavoro

IRCCS Fondazione Don Carlo Gnocchi - Milano

Risultato della ricerca: Contributo in rivista › Articolo › peer review

10 Citazioni (Scopus)

Abstract

The aim of the study was to evaluate the type-1 immune response by analyzing T-bet expression in circulating T and B cells in Primary Progressive (PP) and Secondary Progressive (SP) Multiple Sclerosis (MS) patients. We found higher percentages of circulating CD4(+)T-bet(+) and CD8(+)T-bet(+) T cells in SPMS and PPMS than in remitting-relapsing MS patients and controls. Moreover, in SPMS, we observed a positive correlation between the percentages of circulating CD4(+)T-bet(+) or CD8(+)T-bet(+) T cells and disease severity. The increased percentages of Th1 and Tc1 cells suggest that MS progressive forms, unlike RRMS, are characterized by a permanent peripheral type-1 immune activation.

Lingua originale	Inglese
pagine (da-a)	1-5
Numero di pagine	5
Rivista	Journal of Neuroimmunology
Volume	2012
Numero di pubblicazione	Maggio
DOI	https://doi.org/10.1016/j.jneuroim.2012.04.019
Stato di pubblicazione	Pubblicato - 2012

All Science Journal Classification (ASJC) codes

Immunologia e Allergia
Immunologia
Neurologia
Neurologia (clinica)

Keywords

multiple sclerosis

Accesso al documento

10.1016/j.jneuroim.2012.04.019

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abstract = "The aim of the study was to evaluate the type-1 immune response by analyzing T-bet expression in circulating T and B cells in Primary Progressive (PP) and Secondary Progressive (SP) Multiple Sclerosis (MS) patients. We found higher percentages of circulating CD4(+)T-bet(+) and CD8(+)T-bet(+) T cells in SPMS and PPMS than in remitting-relapsing MS patients and controls. Moreover, in SPMS, we observed a positive correlation between the percentages of circulating CD4(+)T-bet(+) or CD8(+)T-bet(+) T cells and disease severity. The increased percentages of Th1 and Tc1 cells suggest that MS progressive forms, unlike RRMS, are characterized by a permanent peripheral type-1 immune activation.",

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T1 - Type 1 immune response in progressive Multiple Sclerosis

AU - Frisullo, Giovanni

AU - Plantone, Domenico

AU - Marti, Alessandro

AU - Iorio, Raffaele

AU - Damato, V

AU - Bianco, Alessandro

AU - Nociti, Viviana

AU - Patanella, Agata Katia

AU - Batocchi, Anna Paola

PY - 2012

Y1 - 2012

N2 - The aim of the study was to evaluate the type-1 immune response by analyzing T-bet expression in circulating T and B cells in Primary Progressive (PP) and Secondary Progressive (SP) Multiple Sclerosis (MS) patients. We found higher percentages of circulating CD4(+)T-bet(+) and CD8(+)T-bet(+) T cells in SPMS and PPMS than in remitting-relapsing MS patients and controls. Moreover, in SPMS, we observed a positive correlation between the percentages of circulating CD4(+)T-bet(+) or CD8(+)T-bet(+) T cells and disease severity. The increased percentages of Th1 and Tc1 cells suggest that MS progressive forms, unlike RRMS, are characterized by a permanent peripheral type-1 immune activation.

AB - The aim of the study was to evaluate the type-1 immune response by analyzing T-bet expression in circulating T and B cells in Primary Progressive (PP) and Secondary Progressive (SP) Multiple Sclerosis (MS) patients. We found higher percentages of circulating CD4(+)T-bet(+) and CD8(+)T-bet(+) T cells in SPMS and PPMS than in remitting-relapsing MS patients and controls. Moreover, in SPMS, we observed a positive correlation between the percentages of circulating CD4(+)T-bet(+) or CD8(+)T-bet(+) T cells and disease severity. The increased percentages of Th1 and Tc1 cells suggest that MS progressive forms, unlike RRMS, are characterized by a permanent peripheral type-1 immune activation.

KW - multiple sclerosis

UR - https://publicatt.unicatt.it/handle/10807/7770

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U2 - 10.1016/j.jneuroim.2012.04.019

DO - 10.1016/j.jneuroim.2012.04.019

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JO - Journal of Neuroimmunology

JF - Journal of Neuroimmunology

IS - Maggio

ER -

Type 1 immune response in progressive Multiple Sclerosis

Abstract

All Science Journal Classification (ASJC) codes

Keywords

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