Type 1 immune response in progressive Multiple Sclerosis

Giovanni Frisullo, Domenico Plantone, Alessandro Marti, Raffaele Iorio, Alessandro Bianco, Viviana Nociti, Agata Katia Patanella, Anna Paola Batocchi, V Damato

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9 Citazioni (Scopus)

Abstract

The aim of the study was to evaluate the type-1 immune response by analyzing T-bet expression in circulating T and B cells in Primary Progressive (PP) and Secondary Progressive (SP) Multiple Sclerosis (MS) patients. We found higher percentages of circulating CD4(+)T-bet(+) and CD8(+)T-bet(+) T cells in SPMS and PPMS than in remitting-relapsing MS patients and controls. Moreover, in SPMS, we observed a positive correlation between the percentages of circulating CD4(+)T-bet(+) or CD8(+)T-bet(+) T cells and disease severity. The increased percentages of Th1 and Tc1 cells suggest that MS progressive forms, unlike RRMS, are characterized by a permanent peripheral type-1 immune activation.
Lingua originaleEnglish
pagine (da-a)1-5
Numero di pagine5
RivistaJournal of Neuroimmunology
Volume2012
Stato di pubblicazionePubblicato - 2012

Keywords

  • multiple sclerosis

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