TY - JOUR
T1 - Type 1 immune response in progressive Multiple Sclerosis
AU - Frisullo, Giovanni
AU - Plantone, Domenico
AU - Marti, Alessandro
AU - Iorio, Raffaele
AU - Damato, Valentina
AU - Bianco, Alessandro
AU - Nociti, Viviana
AU - Patanella, Agata Katia
AU - Batocchi, Anna Paola
PY - 2012
Y1 - 2012
N2 - The aim of the study was to evaluate the type-1 immune response by analyzing T-bet expression in circulating T and B cells in Primary Progressive (PP) and Secondary Progressive (SP) Multiple Sclerosis (MS) patients. We found higher percentages of circulating CD4(+)T-bet(+) and CD8(+)T-bet(+) T cells in SPMS and PPMS than in remitting-relapsing MS patients and controls. Moreover, in SPMS, we observed a positive correlation between the percentages of circulating CD4(+)T-bet(+) or CD8(+)T-bet(+) T cells and disease severity. The increased percentages of Th1 and Tc1 cells suggest that MS progressive forms, unlike RRMS, are characterized by a permanent peripheral type-1 immune activation.
AB - The aim of the study was to evaluate the type-1 immune response by analyzing T-bet expression in circulating T and B cells in Primary Progressive (PP) and Secondary Progressive (SP) Multiple Sclerosis (MS) patients. We found higher percentages of circulating CD4(+)T-bet(+) and CD8(+)T-bet(+) T cells in SPMS and PPMS than in remitting-relapsing MS patients and controls. Moreover, in SPMS, we observed a positive correlation between the percentages of circulating CD4(+)T-bet(+) or CD8(+)T-bet(+) T cells and disease severity. The increased percentages of Th1 and Tc1 cells suggest that MS progressive forms, unlike RRMS, are characterized by a permanent peripheral type-1 immune activation.
KW - multiple sclerosis
KW - multiple sclerosis
UR - http://hdl.handle.net/10807/7770
U2 - 10.1016/j.jneuroim.2012.04.019
DO - 10.1016/j.jneuroim.2012.04.019
M3 - Article
SN - 0165-5728
VL - 2012
SP - 1
EP - 5
JO - Journal of Neuroimmunology
JF - Journal of Neuroimmunology
ER -