Type 1 immune response in progressive Multiple Sclerosis

Giovanni Frisullo; Domenico Plantone; Alessandro Marti; Raffaele Iorio; V Damato; Alessandro Bianco; Viviana Nociti; Agata Katia Patanella; Anna Paola Batocchi

Type 1 immune response in progressive Multiple Sclerosis

Giovanni Frisullo, Domenico Plantone, Alessandro Marti, Raffaele Iorio, V Damato, Alessandro Bianco, Viviana Nociti, Agata Katia Patanella, Anna Paola Batocchi

Risultato della ricerca: Contributo in rivista › Articolo in rivista › peer review

10 Citazioni (Scopus)

Abstract

The aim of the study was to evaluate the type-1 immune response by analyzing T-bet expression in circulating T and B cells in Primary Progressive (PP) and Secondary Progressive (SP) Multiple Sclerosis (MS) patients. We found higher percentages of circulating CD4(+)T-bet(+) and CD8(+)T-bet(+) T cells in SPMS and PPMS than in remitting-relapsing MS patients and controls. Moreover, in SPMS, we observed a positive correlation between the percentages of circulating CD4(+)T-bet(+) or CD8(+)T-bet(+) T cells and disease severity. The increased percentages of Th1 and Tc1 cells suggest that MS progressive forms, unlike RRMS, are characterized by a permanent peripheral type-1 immune activation.

Lingua originale	English
pagine (da-a)	1-5
Numero di pagine	5
Rivista	Journal of Neuroimmunology
Volume	2012
Stato di pubblicazione	Pubblicato - 2012

Keywords

multiple sclerosis

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title = "Type 1 immune response in progressive Multiple Sclerosis",

abstract = "The aim of the study was to evaluate the type-1 immune response by analyzing T-bet expression in circulating T and B cells in Primary Progressive (PP) and Secondary Progressive (SP) Multiple Sclerosis (MS) patients. We found higher percentages of circulating CD4(+)T-bet(+) and CD8(+)T-bet(+) T cells in SPMS and PPMS than in remitting-relapsing MS patients and controls. Moreover, in SPMS, we observed a positive correlation between the percentages of circulating CD4(+)T-bet(+) or CD8(+)T-bet(+) T cells and disease severity. The increased percentages of Th1 and Tc1 cells suggest that MS progressive forms, unlike RRMS, are characterized by a permanent peripheral type-1 immune activation.",

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author = "Giovanni Frisullo and Domenico Plantone and Alessandro Marti and Raffaele Iorio and V Damato and Alessandro Bianco and Viviana Nociti and Patanella, {Agata Katia} and Batocchi, {Anna Paola}",

year = "2012",

language = "English",

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journal = "Journal of Neuroimmunology",

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T1 - Type 1 immune response in progressive Multiple Sclerosis

AU - Frisullo, Giovanni

AU - Plantone, Domenico

AU - Marti, Alessandro

AU - Iorio, Raffaele

AU - Damato, V

AU - Bianco, Alessandro

AU - Nociti, Viviana

AU - Patanella, Agata Katia

AU - Batocchi, Anna Paola

PY - 2012

Y1 - 2012

N2 - The aim of the study was to evaluate the type-1 immune response by analyzing T-bet expression in circulating T and B cells in Primary Progressive (PP) and Secondary Progressive (SP) Multiple Sclerosis (MS) patients. We found higher percentages of circulating CD4(+)T-bet(+) and CD8(+)T-bet(+) T cells in SPMS and PPMS than in remitting-relapsing MS patients and controls. Moreover, in SPMS, we observed a positive correlation between the percentages of circulating CD4(+)T-bet(+) or CD8(+)T-bet(+) T cells and disease severity. The increased percentages of Th1 and Tc1 cells suggest that MS progressive forms, unlike RRMS, are characterized by a permanent peripheral type-1 immune activation.

AB - The aim of the study was to evaluate the type-1 immune response by analyzing T-bet expression in circulating T and B cells in Primary Progressive (PP) and Secondary Progressive (SP) Multiple Sclerosis (MS) patients. We found higher percentages of circulating CD4(+)T-bet(+) and CD8(+)T-bet(+) T cells in SPMS and PPMS than in remitting-relapsing MS patients and controls. Moreover, in SPMS, we observed a positive correlation between the percentages of circulating CD4(+)T-bet(+) or CD8(+)T-bet(+) T cells and disease severity. The increased percentages of Th1 and Tc1 cells suggest that MS progressive forms, unlike RRMS, are characterized by a permanent peripheral type-1 immune activation.

KW - multiple sclerosis

UR - http://hdl.handle.net/10807/7770

M3 - Article

SN - 0165-5728

VL - 2012

SP - 1

EP - 5

JO - Journal of Neuroimmunology

JF - Journal of Neuroimmunology

ER -

Type 1 immune response in progressive Multiple Sclerosis

Abstract

Keywords

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