Two proline-rich peptides from pig (Sus scrofa) salivary glands generated by a pre-secretory pathway underlying the action of a proteinase cleaving Pro-Ala bonds

Maria Patamia; Irene Messana; Raffaele Petruzzelli; Alberto Vitali; Rosanna Inzitari; Tiziana Cabras; Chiara Fanali; Emanuele Scarano; Alessia Maria Contucci; Antonio Galtieri; Massimo Castagnola

Two proline-rich peptides from pig (Sus scrofa) salivary glands generated by a pre-secretory pathway underlying the action of a proteinase cleaving Pro-Ala bonds

Maria Patamia, Irene Messana, Raffaele Petruzzelli, Alberto Vitali, Rosanna Inzitari, Tiziana Cabras, Chiara Fanali, Emanuele Scarano, Alessia Maria Contucci, Antonio Galtieri, Massimo Castagnola

Risultato della ricerca: Contributo in rivista › Articolo in rivista

Abstract

The primary structures of two salivary proline-rich peptides (PRP-SP-A, M 6156.0 amu and PRP-SP-B, M 1905.0 amu), from pig (Sus scrofa) were determined. The PRP-SP-B peptide, 21 residues long, overlaps with a sequence repeated 43 times in three deposited cDNAs coding for PRP proteins cloned from porcine parotid glands (Swiss-Prot codes: Q95JC9, Q95JD1, Q95JD0). PRP-SP-A peptide, 56 amino acid residues long, overlaps with the N-terminus repeats of Q95JC9 and Q95JD1 and it is phosphorylated at Ser 12 and 14. The two peptides were found both in whole saliva and in granules from pig parotid glands. The biosynthesis of the two peptides implies the action of a proteinase responsible for Pro down arrow Ala cleavage in the pre-secretory process. (c) 2005 Elsevier Inc. All rights reserved.

Lingua originale	English
pagine (da-a)	1550-1559
Numero di pagine	10
Rivista	Peptides
Stato di pubblicazione	Pubblicato - 2005

Keywords

PEPTIDES
SALIVARY
SCROFA

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title = "Two proline-rich peptides from pig (Sus scrofa) salivary glands generated by a pre-secretory pathway underlying the action of a proteinase cleaving Pro-Ala bonds",

abstract = "The primary structures of two salivary proline-rich peptides (PRP-SP-A, M 6156.0 amu and PRP-SP-B, M 1905.0 amu), from pig (Sus scrofa) were determined. The PRP-SP-B peptide, 21 residues long, overlaps with a sequence repeated 43 times in three deposited cDNAs coding for PRP proteins cloned from porcine parotid glands (Swiss-Prot codes: Q95JC9, Q95JD1, Q95JD0). PRP-SP-A peptide, 56 amino acid residues long, overlaps with the N-terminus repeats of Q95JC9 and Q95JD1 and it is phosphorylated at Ser 12 and 14. The two peptides were found both in whole saliva and in granules from pig parotid glands. The biosynthesis of the two peptides implies the action of a proteinase responsible for Pro down arrow Ala cleavage in the pre-secretory process. (c) 2005 Elsevier Inc. All rights reserved.",

keywords = "PEPTIDES, SALIVARY, SCROFA, PEPTIDES, SALIVARY, SCROFA",

author = "Maria Patamia and Irene Messana and Raffaele Petruzzelli and Alberto Vitali and Rosanna Inzitari and Tiziana Cabras and Chiara Fanali and Emanuele Scarano and Contucci, {Alessia Maria} and Antonio Galtieri and Massimo Castagnola",

year = "2005",

language = "English",

pages = "1550--1559",

journal = "Peptides",

issn = "0196-9781",

publisher = "Elsevier Science Incorporated / NY Journals:Madison Square Station, PO Box 882:New York, NY 10159:(212)633-3730, EMAIL: [email protected], INTERNET: http://www.elsevier.com, Fax: (212)633-3680",

}

TY - JOUR

T1 - Two proline-rich peptides from pig (Sus scrofa) salivary glands generated by a pre-secretory pathway underlying the action of a proteinase cleaving Pro-Ala bonds

AU - Patamia, Maria

AU - Messana, Irene

AU - Petruzzelli, Raffaele

AU - Vitali, Alberto

AU - Inzitari, Rosanna

AU - Cabras, Tiziana

AU - Fanali, Chiara

AU - Scarano, Emanuele

AU - Contucci, Alessia Maria

AU - Galtieri, Antonio

AU - Castagnola, Massimo

PY - 2005

Y1 - 2005

N2 - The primary structures of two salivary proline-rich peptides (PRP-SP-A, M 6156.0 amu and PRP-SP-B, M 1905.0 amu), from pig (Sus scrofa) were determined. The PRP-SP-B peptide, 21 residues long, overlaps with a sequence repeated 43 times in three deposited cDNAs coding for PRP proteins cloned from porcine parotid glands (Swiss-Prot codes: Q95JC9, Q95JD1, Q95JD0). PRP-SP-A peptide, 56 amino acid residues long, overlaps with the N-terminus repeats of Q95JC9 and Q95JD1 and it is phosphorylated at Ser 12 and 14. The two peptides were found both in whole saliva and in granules from pig parotid glands. The biosynthesis of the two peptides implies the action of a proteinase responsible for Pro down arrow Ala cleavage in the pre-secretory process. (c) 2005 Elsevier Inc. All rights reserved.

AB - The primary structures of two salivary proline-rich peptides (PRP-SP-A, M 6156.0 amu and PRP-SP-B, M 1905.0 amu), from pig (Sus scrofa) were determined. The PRP-SP-B peptide, 21 residues long, overlaps with a sequence repeated 43 times in three deposited cDNAs coding for PRP proteins cloned from porcine parotid glands (Swiss-Prot codes: Q95JC9, Q95JD1, Q95JD0). PRP-SP-A peptide, 56 amino acid residues long, overlaps with the N-terminus repeats of Q95JC9 and Q95JD1 and it is phosphorylated at Ser 12 and 14. The two peptides were found both in whole saliva and in granules from pig parotid glands. The biosynthesis of the two peptides implies the action of a proteinase responsible for Pro down arrow Ala cleavage in the pre-secretory process. (c) 2005 Elsevier Inc. All rights reserved.

KW - PEPTIDES

KW - SALIVARY

KW - SCROFA

KW - PEPTIDES

KW - SALIVARY

KW - SCROFA

UR - http://hdl.handle.net/10807/25607

M3 - Article

SN - 0196-9781

SP - 1550

EP - 1559

JO - Peptides

JF - Peptides

ER -

Two proline-rich peptides from pig (Sus scrofa) salivary glands generated by a pre-secretory pathway underlying the action of a proteinase cleaving Pro-Ala bonds

Abstract

Keywords

Altri file e collegamenti

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