Tumour necrosis factor alpha in segmental colitis associated with diverticula

Cesare Hassan, E Ierardi, G Meucci, A Zullo, G Imperiali, V De Francesco, C Panella, S Morini, G. Minoli

Risultato della ricerca: Contributo in rivistaArticolo in rivista

20 Citazioni (Scopus)

Abstract

The pathogenesis of segmental colitis associated with diverticula (SCAD) is unclear, but tumour necrosis factor alpha (TNF-alpha) has been shown to play a pivotal role in the pathogenesis of inflammatory bowel diseases. The aim of this study was to assess TNF-alpha levels in patients with SCAD. In a post hoc analysis of a prospective multicenter study, tissue samples from 13 patients diagnosed with SCAD were subjected to histological analyses. The severity of the inflammation was assessed by means of a histological score and histomorphometry (number of inflammatory cells/mm2). Immunohistochemical staining with an antibody against TNF-alpha was performed on all biopsies and the degree of staining expressed as the percentage of positive stromal cells/1000 counted (TNF-alpha score). Matched patients with irritable bowel syndrome (IBS) were used as controls. Over-expression of TNF-alpha was found in all SCAD patients (38.6 +/- 10.4%), and it was associated with a high histological score (2.5 +/- 0.5) and neutrophil cell count (16.3 +/- 3/mm2). These values were distinctly higher than those found in the IBS controls. Our data suggest that TNF-alpha activity is involved in SCAD pathogenesis, similarly to what occurs in Crohn's disease and ulcerative colitis.
Lingua originaleEnglish
pagine (da-a)1865-1868
Numero di pagine4
RivistaDigestive Diseases and Sciences
Volume53
DOI
Stato di pubblicazionePubblicato - 2008
Pubblicato esternamente

Keywords

  • Aged
  • Aged, 80 and over
  • Colitis
  • Colonoscopy
  • Diverticulum
  • Female
  • Humans
  • Immunoenzyme Techniques
  • Male
  • Middle Aged
  • Prospective Studies
  • Tumor Necrosis Factor-alpha

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