Tumor size as a prognostic factor in patients with stage IIa colon cancer

Alberto Biondi, Riccardo Ricci, Claudio Coco, Domenico D'Ugo, Roberto Persiani, Francesco Santullo, Ferdinando Carlo Maria Cananzi, Valeria Fico, Flavio Tirelli, Gianluca Rizzo, Claudio Mattana, Ferdinando C.M. Cananzi

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12 Citazioni (Scopus)

Abstract

Background: The aim of this study was to identify stage II colon cancer patients with a high risk of recurrence. Methods: All patients who underwent surgery for stage II colon cancer (CC) were retrospectively enrolled and sub-grouped according to TNM staging (IIa-b-c) and stage IIa in high (IIaHR) and low risk (IIaLR) according to pathologic features.The primary outcomes measured were the 5-year overall survival (OS) and disease-free survival (DFS). Results: A total of 214 patients were reviewed. Only a maximum tumor diameter<4 cm in the IIaLR group was associated with a higher recurrence rate than a large tumor size (5-year DFS 71.7%vs.87.6%, p = 0.028).The DFS in the large IIaLR CC group was better than that in the IIaHR and IIb-c groups (5-year DFS: 92.7%vs.79.3%, p = 0.023). In contrast, the recurrence rate in the small IIaLR CC group was similar to that in the IIaHR, IIb-c stage CC group. Conclusions: In stage IIa CC evaluation of the tumor size as a prognostic factor may help identify patients who could benefit from additional postoperative therapy.
Lingua originaleEnglish
pagine (da-a)71-77
Numero di pagine7
RivistaTHE AMERICAN JOURNAL OF SURGERY
Volume215
DOI
Stato di pubblicazionePubblicato - 2018

Keywords

  • Adiuvant treatment
  • Colorectal cancer
  • Prognosis
  • Stage II
  • Surgery
  • Tumor size

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