Tumor necrosis factor-alpha antagonism improves endothelial dysfunction in patients with Crohn's disease

Alessandro Armuzzi, Nadia Mores, Carmine Cardillo, Francesca Schinzari, Barbara De Pascalis, Domenico Melina, M Tesauro

Risultato della ricerca: Contributo in rivistaArticolo in rivistapeer review

47 Citazioni (Scopus)

Abstract

This study assessed the presence of endothelial dysfunction in patients with inflammatory bowel diseases (IBDs) and evaluated the possible role of tumor necrosis factor (TNF)-alpha in the pathophysiology of this abnormality. Similar elevations in circulating markers of inflammation (C-reactive protein and interleukin-6) were observed in Crohn's disease and ulcerative colitis compared to controls. Endothelium-dependent vasodilation to acetylcholine was impaired in Crohn's disease, but not in ulcerative colitis. Endothelium-independent vasodilation to sodium nitroprusside, by contrast, was not different among the three groups. The TNF-alpha neutralizing antibody, infliximab, enhanced the responsiveness to acetylcholine, but not to nitroprusside, in Crohn's disease, without modifying vascular responses to both drugs in ulcerative colitis. In conclusion, despite comparable degrees of systemic inflammation in the two IBDs, endothelial dysfunction is a selective feature of Crohn's disease and is beneficially affected by intravascular TNF-alpha neutralization. These findings underscore the role of selective cytokine targeting in improving endothelial function in patients with Crohn's disease.
Lingua originaleEnglish
pagine (da-a)70-76
Numero di pagine7
RivistaCLINICAL PHARMACOLOGY & THERAPEUTICS
Volume83
DOI
Stato di pubblicazionePubblicato - 2008

Keywords

  • endothelium

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