Tumor lysis syndrome: review of pathogenesis, risk factors and management of a medical emergency

Livio Pagano, Marianna Criscuolo, Luana Fianchi

Risultato della ricerca: Contributo in rivistaArticolo in rivista

14 Citazioni (Scopus)

Abstract

Tumor lysis syndrome (TLS) is a rare but potentially life-threatening complication of neoplasms, preferentially hematological malignancies. Well known since at least ninety years ago, this condition can be misdiagnosed and incorrectly managed due to rapid onset of symptoms, sometimes overlapping with cancer-derived clinical conditions. Our purpose is to discuss some old and new issues of this syndrome. Predisposing factors as type of malignancy, chemotherapy regimen and age are promptly available and useful tools for inducing TLS suspicion. Management of clinical syndrome requires hydration, fluid balance, electrolytes and hyperuricemia correction, and ultimately dialysis when acute kidney injury is worsening.
Lingua originaleEnglish
pagine (da-a)1-12
Numero di pagine12
RivistaExpert Review of Hematology
DOI
Stato di pubblicazionePubblicato - 2016

Keywords

  • Tumor lysis syndrome
  • allopurinol
  • drug induced
  • rasburicase

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