Tuberculosis patients are characterized by a low-IFN-γ/high-TNF-α response to methylated HBHA produced in M. smegmatis

P Molicotti; Alessandra Bua; M Cubeddu; S Cannas; Giovanni Delogu; S. Zanetti

doi:10.1016/j.diagmicrobio.2011.08.010

Tuberculosis patients are characterized by a low-IFN-γ/high-TNF-α response to methylated HBHA produced in M. smegmatis

P Molicotti, Alessandra Bua, M Cubeddu, S Cannas, Giovanni Delogu, S. Zanetti

Risultato della ricerca: Contributo in rivista › Articolo › peer review

12 Citazioni (Scopus)

Abstract

Whole blood from Mycobacterium tuberculosis-infected subjects was stimulated with heparin-binding hemagglutinin (HBHA). Tuberculosis (TB) patients showed an HBHA-specific T-cell response characterized by low-IFN-γ/high-TNF-α secretion, while asymptomatic subjects with latent infection (LTBI) and TB patients under therapy showed a pattern with high IFN-γ/low TNF-α. These results underscore the usefulness of HBHA in helping to distinguish LTBI subjects versus TB patients.

Lingua originale	Inglese
pagine (da-a)	449-452
Numero di pagine	4
Rivista	Diagnostic Microbiology and Infectious Disease
Volume	71
DOI	https://doi.org/10.1016/j.diagmicrobio.2011.08.010
Stato di pubblicazione	Pubblicato - 2011

Keywords

Bacterial Proteins
Cells, Cultured
Humans
Interferon-gamma
Leukocytes, Mononuclear
Membrane Proteins
Mycobacterium smegmatis
Mycobacterium tuberculosis
Recombinant Proteins
Tuberculosis
Tumor Necrosis Factor-alpha

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10.1016/j.diagmicrobio.2011.08.010

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abstract = "Whole blood from Mycobacterium tuberculosis-infected subjects was stimulated with heparin-binding hemagglutinin (HBHA). Tuberculosis (TB) patients showed an HBHA-specific T-cell response characterized by low-IFN-γ/high-TNF-α secretion, while asymptomatic subjects with latent infection (LTBI) and TB patients under therapy showed a pattern with high IFN-γ/low TNF-α. These results underscore the usefulness of HBHA in helping to distinguish LTBI subjects versus TB patients.",

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author = "P Molicotti and Alessandra Bua and M Cubeddu and S Cannas and Giovanni Delogu and S. Zanetti",

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doi = "10.1016/j.diagmicrobio.2011.08.010",

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journal = "Diagnostic Microbiology and Infectious Disease",

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T1 - Tuberculosis patients are characterized by a low-IFN-γ/high-TNF-α response to methylated HBHA produced in M. smegmatis

AU - Molicotti, P

AU - Bua, Alessandra

AU - Cubeddu, M

AU - Cannas, S

AU - Delogu, Giovanni

AU - Zanetti, S.

PY - 2011

Y1 - 2011

N2 - Whole blood from Mycobacterium tuberculosis-infected subjects was stimulated with heparin-binding hemagglutinin (HBHA). Tuberculosis (TB) patients showed an HBHA-specific T-cell response characterized by low-IFN-γ/high-TNF-α secretion, while asymptomatic subjects with latent infection (LTBI) and TB patients under therapy showed a pattern with high IFN-γ/low TNF-α. These results underscore the usefulness of HBHA in helping to distinguish LTBI subjects versus TB patients.

AB - Whole blood from Mycobacterium tuberculosis-infected subjects was stimulated with heparin-binding hemagglutinin (HBHA). Tuberculosis (TB) patients showed an HBHA-specific T-cell response characterized by low-IFN-γ/high-TNF-α secretion, while asymptomatic subjects with latent infection (LTBI) and TB patients under therapy showed a pattern with high IFN-γ/low TNF-α. These results underscore the usefulness of HBHA in helping to distinguish LTBI subjects versus TB patients.

KW - Bacterial Proteins

KW - Cells, Cultured

KW - Humans

KW - Interferon-gamma

KW - Leukocytes, Mononuclear

KW - Membrane Proteins

KW - Mycobacterium smegmatis

KW - Mycobacterium tuberculosis

KW - Recombinant Proteins

KW - Tuberculosis

KW - Tumor Necrosis Factor-alpha

KW - Bacterial Proteins

KW - Cells, Cultured

KW - Humans

KW - Interferon-gamma

KW - Leukocytes, Mononuclear

KW - Membrane Proteins

KW - Mycobacterium smegmatis

KW - Mycobacterium tuberculosis

KW - Recombinant Proteins

KW - Tuberculosis

KW - Tumor Necrosis Factor-alpha

UR - http://hdl.handle.net/10807/7873

U2 - 10.1016/j.diagmicrobio.2011.08.010

DO - 10.1016/j.diagmicrobio.2011.08.010

M3 - Article

SN - 0732-8893

VL - 71

SP - 449

EP - 452

JO - Diagnostic Microbiology and Infectious Disease

JF - Diagnostic Microbiology and Infectious Disease

ER -

Tuberculosis patients are characterized by a low-IFN-γ/high-TNF-α response to methylated HBHA produced in M. smegmatis

Abstract

Keywords

OSS delle Nazioni Unite

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