Tuberculosis patients are characterized by a low-IFN-γ/high-TNF-α response to methylated HBHA produced in M. smegmatis

Giovanni Delogu, Alessandra Bua, P Molicotti, M Cubeddu, S Cannas, S. Zanetti

Risultato della ricerca: Contributo in rivistaArticolo in rivistapeer review

12 Citazioni (Scopus)

Abstract

Whole blood from Mycobacterium tuberculosis-infected subjects was stimulated with heparin-binding hemagglutinin (HBHA). Tuberculosis (TB) patients showed an HBHA-specific T-cell response characterized by low-IFN-γ/high-TNF-α secretion, while asymptomatic subjects with latent infection (LTBI) and TB patients under therapy showed a pattern with high IFN-γ/low TNF-α. These results underscore the usefulness of HBHA in helping to distinguish LTBI subjects versus TB patients.
Lingua originaleEnglish
pagine (da-a)449-452
Numero di pagine4
RivistaDiagnostic Microbiology and Infectious Disease
Volume71
DOI
Stato di pubblicazionePubblicato - 2011

Keywords

  • Bacterial Proteins
  • Cells, Cultured
  • Humans
  • Interferon-gamma
  • Leukocytes, Mononuclear
  • Membrane Proteins
  • Mycobacterium smegmatis
  • Mycobacterium tuberculosis
  • Recombinant Proteins
  • Tuberculosis
  • Tumor Necrosis Factor-alpha

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