Trimethyltin-induced differential expression of PAR subtypes in reactive astrocytes of the rat hippocampus

Maria Concetta Geloso, Valentina Corvino, Enrico Guadagni, Fabrizio Michetti, Elena Pompili, Stefania Lucia Nori, Lorenzo Fumagalli

Risultato della ricerca: Contributo in rivistaArticolo in rivistapeer review

Abstract

Thrombin, its main inhibitor (protease nexin-1) and its related receptors (protease-activated receptors, PAR-1,-2, -3, -4) were studied in rat hippocampus following administration of trimethyltin (TMT), a neurotoxin inducing neuronal degeneration and reactive gliosis. Reverse transcriptase-polymerase chain reaction (RT-PCR) and immunohistochemistry revealed that while expression of prothrombin and protease nexin-1 did not change significantly in TMT-treated hippocampi, PARs (in particular PAR-1 and to a lesser extent PAR-2 and PAR-3) were upregulated in reactive astrocytes, suggesting their involvement in neurodegeneration and in the consequent response of the nervous tissue.
Lingua originaleEnglish
pagine (da-a)93-98
Numero di pagine6
RivistaMolecular Brain Research
Stato di pubblicazionePubblicato - 2004

Keywords

  • Astrocyte
  • Neurodegeneration
  • Protease-activated receptor
  • Thrombin
  • Trimethyltin

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