Trigeminal satellite cells express functional calcitonin gene-related peptide receptors, whose activation enhances interleukin-1β pro-inflammatory effects.

Lucia Lisi, Giuseppe Tringali, Pierluigi Navarra, Cinzia Dello Russo, Alice De Corato, Alessandro Capuano, Antonella Tramutola

Risultato della ricerca: Contributo in rivistaArticolo in rivista

Abstract

Calcitonin gene-related peptide (CGRP) is the main mediator of trigeminal pain signal. Functional CGRP receptors were detected in trigeminal satellite cells, a specialized type of glia found within the sensory ganglia. CGRP displayed modest pro-inflammatory effects per se on trigeminal satellite cells, while it significantly enhanced IL-1β actions, increasing the expression and activity of cycloxygenase 2 as well as the expression of the inducible form of nitric oxide synthase and IL-1β. CGRP effects were reverted by a specific CGRP receptor antagonist and mimicked by elevation of intracellular cAMP levels. CGRP exerted also minor proinflammatory effects on cortical astrocytes.
Lingua originaleEnglish
pagine (da-a)39-46
Numero di pagine8
RivistaJournal of Neuroimmunology
Volume2011
Stato di pubblicazionePubblicato - 2011

Keywords

  • CGRP
  • Cortical astrocytes
  • IL-1 Beta
  • Migraine
  • Trigeminal satellite cells

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