Trends in pediatric epilepsy surgery in Europe between 2008 and 2015: Country-, center-, and age-specific variation

Maria Cristina Barba, Domenica Immacolata Battaglia

Risultato della ricerca: Contributo in rivistaArticolo in rivistapeer review

12 Citazioni (Scopus)

Abstract

Objective: To profile European trends in pediatric epilepsy surgery (<16 years of age) between 2008 and 2015. Methods: We collected information on volumes and types of surgery, pathology, and seizure outcome from 20 recognized epilepsy surgery reference centers in 10 European countries. Results: We analyzed retrospective aggregate data on 1859 operations. The proportion of surgeries significantly increased over time (P <.0001). Engel class I outcome was achieved in 69.3% of children, with no significant improvement between 2008 and 2015. The proportion of histopathological findings consistent with glial scars significantly increased between the ages of 7 and 16 years (P for trend =.0033), whereas that of the remaining pathologies did not vary across ages. A significant increase in unilobar extratemporal surgeries (P for trend =.0047) and a significant decrease in unilobar temporal surgeries (P for trend =.0030) were observed between 2008 and 2015. Conversely, the proportion of multilobar surgeries and unrevealing magnetic resonance imaging cases remained unchanged. Invasive investigations significantly increased, especially stereo-electroencephalography. We found different trends comparing centers starting their activity in the 1990s to those whose programs were developed in the past decade. Multivariate analysis revealed a significant variability of the proportion of the different pathologies and surgical approaches across countries, centers, and age groups between 2008 and 2015. Significance: Between 2008 and 2015, we observed a significant increase in the volume of pediatric epilepsy surgeries, stability in the proportion of Engel class I outcomes, and a modest increment in complexity of the procedures.
Lingua originaleEnglish
pagine (da-a)216-227
Numero di pagine12
RivistaEpilepsia
Volume61
DOI
Stato di pubblicazionePubblicato - 2020

Keywords

  • Adolescent
  • Age Factors
  • Child
  • Child, Preschool
  • Electroencephalography
  • Epilepsy
  • Europe
  • Female
  • Humans
  • Magnetic Resonance Imaging
  • Male
  • Neurosurgery
  • Neurosurgical Procedures
  • Retrospective Studies
  • Seizures
  • Temporal Lobe
  • Treatment Outcome
  • children
  • epilepsy surgery
  • histopathology
  • outcome
  • survey

Fingerprint

Entra nei temi di ricerca di 'Trends in pediatric epilepsy surgery in Europe between 2008 and 2015: Country-, center-, and age-specific variation'. Insieme formano una fingerprint unica.

Cita questo